4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;2-[(Z)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;2-[(Z)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine
• 化学式: C49H44N3O6+
• 分子量: 770.9
• InChiKey: ZFWFZMYQXOKWIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  58
• 可旋转键数：
  8
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Pyrvinium pamoate therapies and methods of use
  申请人：Shepherd Therapeutics, Inc.

  公开号：US10933061B2

  公开（公告）日：2021-03-02

  The disclosure relates to a method of treating cancer by administering to the subject a therapeutically effective amount of a composition comprising pyrvinium pamoate, optionally in combination with at least one additional therapeutic agent or modality.

  本公开涉及一种治疗癌症的方法，其方法是向受试者施用治疗有效量的包含帕莫酸吡维尼的组合物，可选择与至少一种额外的治疗剂或方式联合使用。
• PYRVINIUM PAMOATE THERAPIES AND METHODS OF USE
  申请人：Shepherd Therapeutics, Inc.

  公开号：US20190209549A1

  公开（公告）日：2019-07-11

  The disclosure relates to a method of treating cancer by administering to the subject a therapeutically effective amount of a composition comprising pyrvinium pamoate, optionally in combination with at least one additional therapeutic agent or modality.