5-Chlorosulfonyl-2-(3-oxa-9,23-diazoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzenesulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-Chlorosulfonyl-2-(3-oxa-9,23-diazoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzenesulfonate
• 英文别名: 5-chlorosulfonyl-2-(3-oxa-9,23-diazoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzenesulfonate
• 化学式: C31H30ClN2O6S2+
• 分子量: 626.2
• InChiKey: MPLHNVLQVRSVEE-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  42
• 可旋转键数：
  3
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• POLYMER PARTICLES OR NANO-VECTORS AND USE THEREOF AS A DRUG AND/OR DIAGNOSTIC AGENT
  申请人：Bertrand Philippe

  公开号：US20140219925A1

  公开（公告）日：2014-08-07

  Novel polymer nanovectors or particles and use thereof as medication and/or diagnostic agents.

  新型聚合物纳米载体或颗粒及其作为药物和/或诊断试剂的用途。
• IMAGING AGENTS FOR IMAGING PROTEASE ACTIVITY AND USES THEREOF
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Ser.

  公开号：US20170143851A1

  公开（公告）日：2017-05-25

  Disclosed are imaging agents having the following Formula I: wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.

  揭示了具有以下公式I的成像剂：其中F是近红外荧光色素，S是酶可切割寡肽，Q是荧光猝灭剂分子，M是选择自PEG或其衍生物和靶向配体组成的一组中的一种的基团，其中F、Q和M与酶可切割寡肽的不同氨基酸连接。还揭示了包含这种化合物的组合物，以及使用方法，用于识别体内表达感兴趣蛋白酶的细胞或细胞群的方法，以及通过成像治疗疾病的方法。
• COPOLYMER COMPOSITIONS AND USES THEREOF
  申请人：ETH Zurich

  公开号：EP3093027A1

  公开（公告）日：2016-11-16

  The present invention is directed to non-biodegradable copolymer diagnosis agent that has a low affinity for the mucosa in general and allows the transportation of specific molecules that recognizes specific target biomarkers useful in the diagnosis of a certain number of disorders such as pulmonary, gynecologic, eye and gastrointestinal diseases or disorders, and certain conditions of those diseases (such as fibrosis and inflammation), in particular inflammatory bowel disease, such as Crohn's disease or ulcerative colitis (UC) as well as coeliac disease and cancers such as colorectal cancers.

  本发明涉及一种非生物降解共聚物诊断试剂，其对粘膜的亲和力较低，可以运输识别特定靶标生物标志物的特定分子，用于诊断一定数量的疾病或疾病的特定情况，例如肺部、妇科、眼部和胃肠道疾病或疾病，以及这些疾病的某些情况（例如纤维化和炎症），特别是炎症性肠病，如克罗恩病或溃疡性结肠炎（UC），以及乳糜泻和结直肠癌等癌症。
• Signaling conjugates and methods of use
  申请人：Ventana Medical Systems, Inc.

  公开号：US10041950B2

  公开（公告）日：2018-08-07

  Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.

  本文公开了信号结合物的实施方案、使用信号结合物的方法的实施方案以及包含信号结合物的试剂盒的实施方案。 所公开的信号轭合物包括潜伏反应分子和发色分子，潜伏反应分子可进一步包括适于将潜伏反应分子与发色分子偶联的连接体。 信号共轭物可用于检测生物样本中的一个或多个靶标，并能直接共价沉积在靶标上或靶标附近。 所公开的信号轭合物使用方法的具体实施例包括复用方法。
• Proximity assays using chemical ligation and hapten transfer
  申请人：Ventana Medical Systems, Inc.

  公开号：US10620217B2

  公开（公告）日：2020-04-14

  Methods for in situ detecting proximity of two targets of interest featuring an antibody conjugated with a cleavable bridge component having a detectable moiety and an antibody conjugated with a non-cleavable bridge component. The bridge components each have a chemical ligation group adapted to form a covalent bond under particular conditions and when the targets are in close proximity. Following covalent bond formation, the cleavable bridge component can be cleaved from the antibody, effectively transferring the detectable moiety to the non-cleavable bridge component. Detection of the detectable moiety is indicative of the targets being in close proximity. The methods are compatible with both chromogenic and fluorogenic detection systems. The methods may be used to perform assays wherein one or more than one proximity event is detected on the same slide.

  原位检测两个相关目标是否接近的方法，其特征是抗体与具有可检测分子的可裂解桥接组分和抗体与不可裂解桥接组分共轭。桥组分各有一个化学连接基团，可在特定条件下和目标物靠近时形成共价键。共价键形成后，可裂解桥成分可从抗体上裂解，从而有效地将可检测分子转移到不可裂解桥成分上。可检测分子的检测表明目标物距离很近。这些方法与显色和荧光检测系统兼容。这些方法可用于在同一载玻片上检测一个或多个接近事件的检测。