2-Adamantan-1-yl-1-ethyl-piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Adamantan-1-yl-1-ethyl-piperidine
• 英文别名: 2-Adamantanyl-1-ethylpiperidine；2-(1-adamantyl)-1-ethylpiperidine
• 化学式: C₁₇H₂₉N
• 分子量: 247.424
• InChiKey: JYYNECWKRWLUSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-((3r,5r,7r)-adamantan-1-yl)piperidine 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 39.0h， 生成 2-Adamantan-1-yl-1-ethyl-piperidine
  参考文献：
  名称：

  Synthesis and anti-HIV activity of some new aminoadamantane heterocycles

  摘要：

  A new class of aminoadamantane heterocycles has been synthesized and examined for anti-HIV activity. Three compounds proved to be active against the replication of HIV-1 in MT-4 cells with an EC50 ranging from 3.6 to 75.2 mu M. No activity was noted with any of the compounds against HIV-2. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00320-x

文献信息

• Synthesis and anti-HIV activity of some new aminoadamantane heterocycles
  作者：G. Fytas、G. Stamatiou、G.B. Foscolos、A. Kolocouris、N. Kolocouris、M. Witvrouw、C. Pannecouque、E. De Clercq

  DOI：10.1016/s0960-894x(97)00320-x

  日期：1997.7

  A new class of aminoadamantane heterocycles has been synthesized and examined for anti-HIV activity. Three compounds proved to be active against the replication of HIV-1 in MT-4 cells with an EC50 ranging from 3.6 to 75.2 mu M. No activity was noted with any of the compounds against HIV-2. (C) 1997 Elsevier Science Ltd.