5-[(7,8-dimethoxy-4H-chromen-5-yl)methyl]pyrimidine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[(7,8-dimethoxy-4H-chromen-5-yl)methyl]pyrimidine-2,4-diamine
• 化学式: C₁₆H₁₈N₄O₃
• 分子量: 314.34
• InChiKey: ZYPSBPRHNICRMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted pyrimidines, their synthesis and compositions containing them, their use in medicine and intermediates for making them
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0051879A2

  公开（公告）日：1982-05-19

  Compounds of the formula (1): or a salt, N-oxide or acyl derivative thereof, wherein is a six membered ring optionally containing a hetero atom double bonds, both the phenyl ring and the being optionally substituted except that when does not contain a hetero atom either or both the phenyl ring or must be substituted other than solely by a hydroxy group at the 4-position of the phenyl ring, and that there are no substituents attached to the atom of adjacent to the 6-position of the phenyl ring are useful in the treatment of bacterial infections. A process for preparing these compounds and novel chemical intermediates used in their preparation are disclosed as is the first medical use of the compounds of the formula (I) and pharmaceutical compositions containing them.

  式(1)化合物： 或其盐、N-氧化物或酰基衍生物，其中苯基环和苯基环均可被任选取代，但当不含有杂原子时，苯基环或苯基环均必须被取代，而不是仅被苯基环 4 位上的羟基取代，且与苯基环 6 位相邻的原子上不连接任何取代基。 本发明公开了制备这些化合物的工艺和用于制备这些化合物的新型化学中间体，以及式（I）化合物和含有这些化合物的药物组合物的首次医学用途。
• US4587342A
  申请人：——

  公开号：US4587342A

  公开（公告）日：1986-05-06
• US4761475A
  申请人：——

  公开号：US4761475A

  公开（公告）日：1988-08-02