8-[(3R)-3-amino-1-piperidyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 8-[(3R)-3-amino-1-piperidyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid
• 英文别名: 8-[(3R)-3-aminopiperidin-1-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid
• 化学式: C₁₉H₂₂FN₃O₃
• 分子量: 359.4
• InChiKey: UGRLROASGRWGAN-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  86.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• PHARMACEUTICAL COMPOSITION
  申请人：NAKAGAMI Hiroaki

  公开号：US20070148235A1

  公开（公告）日：2007-06-28

  The present invention relates to a granular pharmaceutical composition comprising a drug having a disagreeable taste, a wax and a sugar alcohol; a method for preparing the same; and a pharmaceutical product for oral administration, comprising the granular composition. The product excellently masks a disagreeable taste possessed by a drug and provides good sensation upon oral administration, and therefore is easily ingested by even the elderly, children, and patients suffering dysphagia. Moreover, the product is suitable for administration using tube.