8-(2-Aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 8-(2-Aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-quinolizine-3-carboxylic acid
• 英文别名: 8-(2-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid
• 化学式: C₁₈H₂₀FN₃O₃
• 分子量: 345.4
• InChiKey: PCUPOFGYQWENHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  86.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 2-PYRIDONE ANTIMICROBIAL COMPOSITIONS
  申请人：Evolva SA

  公开号：EP2621491A1

  公开（公告）日：2013-08-07
• [EN] 2-PYRIDONE ANTIMICROBIAL COMPOSITIONS<br/>[FR] COMPOSITIONS ANTIMICROBIENNES À BASE DE 2-PYRIDONE
  申请人：EVOLVA SA

  公开号：WO2012047487A1

  公开（公告）日：2012-04-12

  Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.