1-Ethyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-Ethyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.24
• InChiKey: MDBBKLHRLDIGIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] CEPHEM COMPOUNDS WITH LATENT REACTIVE GROUPS<br/>[FR] COMPOSÉS DE CÉPHÈME AYANT DES GROUPES RÉACTIFS LATENTS
  申请人：GLADIUS PHARMACEUTICALS CORP

  公开号：WO2019070973A1

  公开（公告）日：2019-04-11

  Cephem and penem compounds having a styrylmethylene moiety at the 3-position in the cephem or penem ring to which a positively charged leaving group is bonded and wherein the leaving group contains a vicinal diol or is bonded to a unsubstituted or substituted catechol. The leaving group can be a positively charge nitrogen leaving group. Cephems include cephalosporins, cephamycins, carbacephems, and oxacephems. Penems include penems, carbapenems and oxapenems. Preferred cephems are cephalosporins. Preferred penems are carbapenems. Compounds exhibit antibiotic activity against Gram-negative bacteria and/or Gram-positive bacteria. Compounds exhibit antibiotic activity against bacteria which exhibit multi-drug resistance. Compounds of the invention exhibit antibiotic activity against bacterial strains which produce extended spectrum beta-lactamases (ESBL), which produce AmpC beta-lactamases or which produce a carbapenemase. Pharmaceutical compositions comprising one or more cephems or penems or methods of treatment of bacterial infections with such compounds and compositions.