N-(2-hydroxyethyl)-4-(1H-6-indazolylamino)-2-methylthio-5-pyrimidinecarboxamide | 342637-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: N-(2-hydroxyethyl)-4-(1H-6-indazolylamino)-2-methylthio-5-pyrimidinecarboxamide
• 英文别名: N-(2-hydroxyethyl)-4-(1H-indazol-6-ylamino)-2-methylsulfanyl-pyrimidine-5-carboxamide；N-(2-hydroxyethyl)-4-(1H-indazol-6-ylamino)-2-methylsulfanylpyrimidine-5-carboxamide
• CAS: 342637-02-9
• 化学式: C₁₅H₁₆N₆O₂S
• 分子量: 344.397
• InChiKey: MVCVFABXKBJEGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• EP1235806A4
  申请人：——

  公开号：EP1235806A4

  公开（公告）日：2004-02-04
• NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES
  申请人：DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD.

  公开号：EP1235806A1

  公开（公告）日：2002-09-04
• [EN] NOVEL 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE 5-PYRIMIDINECARBOXAMIDE ET COMPOSITIONS PHARMACEUTIQUES RENFERMANT CES DERIVES
  申请人：DONG WHA PHARM IND CO LTD

  公开号：WO2001038308A1

  公开（公告）日：2001-05-31

  The present invention relates to novel 5-pyrimidinecarboxamide derivatives and the pharmaceutical compositions containing said derivatives, and more specifically, to 5-pyrimidinecarboxamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. In particular, said 5-pyrimidinecarboxamide derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as a therapeutic agent as well as a preventive agent for hepatitis B and acquired immune deficiency syndrome (AIDS).