Homoserine lactone 1-(dimethylamino)naphthalene-5-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Homoserine lactone 1-(dimethylamino)naphthalene-5-sulfonamide
• 英文别名: 5-(dimethylamino)-N-(2-oxooxolan-3-yl)naphthalene-1-sulfonamide
• 化学式: C₁₆H₁₈N₂O₄S
• 分子量: 334.4
• InChiKey: MAFPHTJPGRTADN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  84.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Modulation of Bacterial Quorum Sensing with Synthetic Ligands
  申请人：Blackwell Helen E.

  公开号：US20080312319A1

  公开（公告）日：2008-12-18

  The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
• Modulation of Bacterial Quorum Sensing With Synthetic Ligands
  申请人：Blackwell Helen E.

  公开号：US20110212860A1

  公开（公告）日：2011-09-01

  The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
• US7910622B2
  申请人：——

  公开号：US7910622B2

  公开（公告）日：2011-03-22
• [EN] MODULATION OF BACTERIAL QUORUM SENSING WITH SYNTHETIC LIGANDS<br/>[FR] MODULATION DE LA DÉTECTION DU QUORUM BACTÉRIEN AVEC DES LIGANDS SYNTHÉTIQUES
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2008116029A1

  公开（公告）日：2008-09-25

  [EN] The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
  [FR] La présente invention concerne des composés et des procédés de modulation de la détection du quorum bactérien. Dans un mode de réalisation, les composés de la présente invention sont capables d'agir en tant que remplacements de ligands de détection du quorum bactérien naturels dans un système de liaison protéine-ligand ; en d'autres termes, ils imitent l'effet de ligands naturels et produisent un effet agoniste. Dans un autre mode de réalisation, les composés de la présente invention sont capables d'agir d'une manière qui perturbe ou inhibe le système de liaison ligand-protéine naturel chez les bactéries de détection de quorum ; en d'autres termes, ils produisent un effet antagoniste. Les composés de la présente invention comprennent des homosérine lactones N-acylées (AHL) composées d'une vaste gamme de groupes acyle.