N,N'-Di-naphthalen-2-yl-terephthalamide | 3771-99-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N'-Di-naphthalen-2-yl-terephthalamide
• 英文别名: 1-N,4-N-dinaphthalen-2-ylbenzene-1,4-dicarboxamide
• CAS: 3771-99-1
• 化学式: C₂₈H₂₀N₂O₂
• 分子量: 416.479
• InChiKey: FCHUGWKYFXFFAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• TRBD-Binding Effectors and Methods for Using the Same to Modulate Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20100160260A1

  公开（公告）日：2010-06-24

  The present invention embraces compounds selected for interacting with the T-pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.
• Screening Method and Compounds for Modulating Telomerase Activity
  申请人：Skordalakes Emmanuel

  公开号：US20120309759A1

  公开（公告）日：2012-12-06

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY
  申请人：The Wistar Institute

  公开号：US20160067257A1

  公开（公告）日：2016-03-10

  The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of telomerase and testing the compound for its ability to modulate the activity of telomerase. Compounds selected for interacting with the T-pocket or Fingers-Palm pocket of telomerase are also provided.
• US5043399A
  申请人：——

  公开号：US5043399A

  公开（公告）日：1991-08-27
• US8377992B2
  申请人：——

  公开号：US8377992B2

  公开（公告）日：2013-02-19