Blazeispirol C

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: Blazeispirol C
• 英文别名: (1R,3'R,4'S,10R,11R,12S,13S)-5-methoxy-4',5',5',6,10,12-hexamethylspiro[14-oxatetracyclo[9.3.2.01,10.02,7]hexadeca-2(7),3,5-triene-13,2'-oxolane]-3'-ol
• 化学式: C₂₅H₃₆O₄
• 分子量: 400.5
• InChiKey: QEVQGAGSLSJTLO-TVHHQFAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them
  申请人：InterMed Discovery GmbH

  公开号：EP2468253A1

  公开（公告）日：2012-06-27

  The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.

  本发明涉及姬松茸提取物和/或特别是一种或多种天然螺三萜类及其衍生物，尤其是从姬松茸中提取的blazeispirol家族中的一种或多种天然螺三萜类及其衍生物的使用或方法（尤其是针对需要此类治疗的动物，特别是人类），作为预防和/或治疗疾病的活性成分、本发明还涉及上述提取物和/或天然化合物或混合物用于治疗上述疾病、紊乱或病症的用途，以及相应的治疗方法，或它们在制造用于上述治疗的药物或保健品配方中的用途。本发明还涉及用于治疗或制备预防和/或治疗上述疾病、失调或病症的药物（包括营养保健品）的上述提取物和/或化合物，以及它们的制备方法。它还涉及包含上述提取物和/或天然化合物的药物或保健品制剂，这些制剂可用于上述预防和/或治疗。它们也可仅用于非治疗目的，如美容。
• Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them
  申请人：Grothe Torsten

  公开号：US20130338219A1

  公开（公告）日：2013-12-19

  The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
• US9453016B2
  申请人：——

  公开号：US9453016B2

  公开（公告）日：2016-09-27
• [EN] TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM<br/>[FR] COMPOSÉS DE SPIRO-CÉTAL TERPÉNOÏDE AVEC DES AGONISTES DE LXR, LEUR UTILISATION ET FORMULATIONS AVEC CEUX-CI
  申请人：INTERMED DISCOVERY GMBH

  公开号：WO2012079721A1

  公开（公告）日：2012-06-21

  The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.

表征谱图