1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-indolin-1-yl-propan-1-one;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-indolin-1-yl-propan-1-one;hydrochloride
• 英文别名: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(2,3-dihydroindol-1-yl)propan-1-one
• 化学式: C₁₉H₁₉NO₃
• 分子量: 309.4
• InChiKey: BQBKFICIXAUOHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS INHIBITING TDG ACTIVITY<br/>[FR] COMPOSÉS INHIBANT L'ACTIVITÉ DE TDG<br/>[ZH] 抑制TDG活性的化合物
  申请人：EPITAS BIOSCIENCES SHANGHAI CO LTD

  公开号：WO2020224396A1

  公开（公告）日：2020-11-12

  本发明提供了一类抑制TDG活性的化合物。具体地，本发明提供了一种如式I所示的具有新颖结构的化合物。本发明的小分子抑制剂对TDG具有优异的抑制作用。
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.
• COMPOUNDS INHIBITING TDG ACTIVITY
  申请人：EPITAS BIOSCIENCES (SHANGHAI) CO., LTD.

  公开号：US20220213070A1

  公开（公告）日：2022-07-07

  The present invention provides a class of compounds inhibiting TDG activity. Specifically, the present invention provides a compound having a novel structure as shown in formula I. The small molecule inhibitor of the present invention has an excellent inhibitory effect on TDG.