DIDS (sodium salt)

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: DIDS (sodium salt)
• 英文别名: disodium;5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
• 化学式: C16H8N2Na2O6S4
• 分子量: 498.5
• InChiKey: GEPAYBXVXXBSKP-SEPHDYHBSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.86
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  220
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME
  申请人：Lee Changjoon Justin

  公开号：US20090131527A1

  公开（公告）日：2009-05-21

  The present invention relates to novel anthranilic acid derivatives represented by Chemical Formula I, and a chloride channel blocking agent containing the anthranilic acid derivative or its pharmacologically acceptable salts as an active ingredient. In another aspect, the present invention relates to a method of accurately and efficiently detecting the intracellular chloride channel inhibition and method of screening a chloride channel blocking agent.

  本发明涉及新颖的由化学式I表示的蒽酰胺衍生物，以及含有该蒽酰胺衍生物或其药理学上可接受的盐作为活性成分的氯通道阻滞剂。在另一个方面，本发明涉及一种准确高效地检测细胞内氯通道抑制和筛选氯通道阻滞剂的方法。
• MACROMOLECULAR CONJUGATES OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREFOR
  申请人：Verkman Alan S.

  公开号：US20080171793A1

  公开（公告）日：2008-07-17

  Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.

  本文提供了生物活性剂，其中包括一种抑制囊性纤维化跨膜导电调节因子（CFTR）离子传输活性的化合物，并且与与表达CFTR的细胞相互作用的大分子相连。本文所描述的生物活性剂可用于治疗与CFTR活性异常增加相关的疾病、疾病后遗症和疾病、疾病后遗症和病症，例如分泌性腹泻。
• Immobilization of biomolecules by enhanced electrophoretic precipitation
  申请人：ELI LILLY AND COMPANY

  公开号：EP0463859A2

  公开（公告）日：1992-01-02

  The present invention provides a method for immobilizing biomolecules on a conductive substrate.

  本发明提供了一种在导电基底上固定生物分子的方法。
• METHOD OF DETECTING NUCLEIC ACID
  申请人：FUSO PHARMACEUTICAL INDUSTRIES LTD.

  公开号：EP0725149A1

  公开（公告）日：1996-08-07

  A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine containing, bound thereto, a label capable of generating a detectable signal or a precursor thereof to thereby form a complex between a nucleic acid, if any, and the polyamine, removing the polyamine which has not formed any complex before or after the conversion of the precursor, if used, into the label, and detecting the label.

  一种检测核酸的方法，包括将疑似携带或含有核酸的固体载体与含有能产生可检测信号的标签或其前体的多胺接触，从而在核酸（如有）和多胺之间形成复合物，去除在前体（如使用）转化为标签之前或之后未形成任何复合物的多胺，并检测标签。
• Organic conductor
  申请人：FUJI XEROX CO., LTD.

  公开号：EP1324352A2

  公开（公告）日：2003-07-02

  The present invention provides an organic conductor comprising a deoxyribonucleic acid (DNA) and an electric charge-donating material bonded to the deoxyribonucleic acid, and an organic conductor comprising at least two DNAs; and an electric charge-transfer substance bonding to each base of the two DNAs.

  本发明提供了一种有机导体，包括脱氧核糖核酸（DNA）和与脱氧核糖核酸结合的电荷捐赠物质，以及一种有机导体，包括至少两个DNA；和与两个DNA的每个碱基结合的电荷转移物质。