Tert-butyl-[2-[[tert-butyl(diphenyl)silyl]oxymethyl]pent-4-ynoxy]-diphenylsilane | 175729-56-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Tert-butyl-[2-[[tert-butyl(diphenyl)silyl]oxymethyl]pent-4-ynoxy]-diphenylsilane
• CAS: 175729-56-3
• 化学式: C₃₈H₄₆O₂Si₂
• 分子量: 590.953
• InChiKey: ODEAGBKJOAYUGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.78
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Tert-butyl-[2-[[tert-butyl(diphenyl)silyl]oxymethyl]pent-4-ynoxy]-diphenylsilane 在 lithium aluminium tetrahydride 、 正丁基锂 、 三氟化硼乙醚 、 三乙胺 作用下， 以 四氢呋喃 、 二乙二醇二甲醚 为溶剂， 反应 21.25h， 生成 (E)-5-((E)-(6S,7R)-7-Hydroxy-2-hydroxymethyl-6-methyl-oct-4-enyloxy)-3-methyl-5-(3-methylsulfanyl-propylsulfanyl)-pent-2-enoic acid ethyl ester
  参考文献：
  名称：

  Synthesis of analogues of monic acids A and C: Potential herbicides and inhibitors of isoleucyl tRNA synthetase

  摘要：

  The m-substituted benzene compounds 16-21 and biphenyl derivatives 25-27 have been synthesised as simplified analogues of monic acids A 3 and C 4. In addition the disubstituted 1,3-dioxanes 41-43 have been prepared and all compounds tested as herbicides and for their ability to inhibit spinach chloroplast isoleucyl tRNA synthetase.

  DOI：

  10.1016/0960-894x(96)00050-9
• 作为产物：
  描述：

  2-((E)-3-Bromo-allyl)-propane-1,3-diol 在 咪唑 、 正丁基锂 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 50.0h， 生成 Tert-butyl-[2-[[tert-butyl(diphenyl)silyl]oxymethyl]pent-4-ynoxy]-diphenylsilane
  参考文献：
  名称：

  Synthesis of analogues of monic acids A and C: Potential herbicides and inhibitors of isoleucyl tRNA synthetase

  摘要：

  The m-substituted benzene compounds 16-21 and biphenyl derivatives 25-27 have been synthesised as simplified analogues of monic acids A 3 and C 4. In addition the disubstituted 1,3-dioxanes 41-43 have been prepared and all compounds tested as herbicides and for their ability to inhibit spinach chloroplast isoleucyl tRNA synthetase.

  DOI：

  10.1016/0960-894x(96)00050-9

文献信息

• Synthesis of analogues of monic acids A and C: Potential herbicides and inhibitors of isoleucyl tRNA synthetase
  作者：Keith Clinch

  DOI：10.1016/0960-894x(96)00050-9

  日期：1996.2

  The m-substituted benzene compounds 16-21 and biphenyl derivatives 25-27 have been synthesised as simplified analogues of monic acids A 3 and C 4. In addition the disubstituted 1,3-dioxanes 41-43 have been prepared and all compounds tested as herbicides and for their ability to inhibit spinach chloroplast isoleucyl tRNA synthetase.