ethyl 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-5-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: ethyl 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-5-carboxylate
• 化学式: C₁₄H₁₄N₂O₄
• 分子量: 274.27
• InChiKey: WHAZOCVUOXOSMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  73.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF
  申请人：Burnham Institute for Medical Research

  公开号：EP2291372A2

  公开（公告）日：2011-03-09
• [EN] INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE LA PHOSPHATASE ALCALINE INTESTINALE ET LEURS UTILISATIONS
  申请人：BURNHAM INST MEDICAL RESEARCH

  公开号：WO2009143150A2

  公开（公告）日：2009-11-26

  Disclosed are modulators, i.e., activators and inhibitors, of Intestinal Alkaline Phosphatase (IAP). Also disclosed are methods for treating bacterial infections of the intestinal tract and methods for maintaining the health of the intestinal tract using IAP activators. Further disclosed are methods to assist in weight gain of emaciated patients and those having reduced or negligible fat absorption using IAP inhibitors.