2-methylsulphonylpropan-1-ol | 21975-08-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-methylsulphonylpropan-1-ol
• 英文别名: 2-(methylsulfonyl)propan-1-ol；2-Methanesulfonylpropan-1-ol；2-methylsulfonylpropan-1-ol
• CAS: 21975-08-6
• 化学式: C₄H₁₀O₃S
• mdl: MFCD26797775
• 分子量: 138.188
• InChiKey: QCKUTCUIBQEELL-UHFFFAOYSA-N

物化性质

• 沸点：
  321.3±25.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 2-methylsulphonylpropan-1-ol 在 吡啶 作用下， 以66%的产率得到2-methylsulfonylpropyl acetate
  参考文献：
  名称：

  Alcudia Gonzalez, F.; Brunet Romero, E.; Garcia Ruano, J. L., Journal of Chemical Research, Miniprint, 1982, # 10, p. 2826 - 2850

  摘要：

  DOI：
• 作为产物：
  描述：

  Methylthio-2-propanol-1 在 sodium periodate 作用下， 以 水 为溶剂， 以84%的产率得到2-methylsulphonylpropan-1-ol
  参考文献：
  名称：

  Alcudia Gonzalez, F.; Brunet Romero, E.; Garcia Ruano, J. L., Journal of Chemical Research, Miniprint, 1982, # 10, p. 2826 - 2850

  摘要：

  DOI：

文献信息

• Synthesis of β-hydroxy sulfones via opening of hydrophilic epoxides with zinc sulfinates in aqueous media
  作者：Nataliya Chumachenko、Paul Sampson

  DOI：10.1016/j.tet.2006.02.043

  日期：2006.5

  Reaction of hydrophilic epoxides (ethylene oxide and propylene oxide) with readily accessible zinc sulfinates in aqueous solution under essentially neutral conditions afforded beta-hydroxy sulfones in good yields. This method avoids the need for organic solvents and produces ZnO as the only major reaction byproduct. 2-(Methylsulfonyl)ethanol, a common reagent for the protection of various functional groups, was obtained by this methodology from ethylene oxide in 78% yield. Reaction of various simple zinc alkane- and benzenesulfinates with propylene oxide proceeded regioselectively in 63-67% yield. The corresponding opening of these epoxides with zinc 1,3-butadiene-1-sulfinate afforded 1-butadienyl beta-hydroxyalkyl sulfones in 30% yield. Mechanistic studies revealed that the yields of these products were limited by their consumption in competing intra- and intermolecular Michael addition processes. (c) 2006 Elsevier Ltd. All rights reserved.
• ALCUDIA, F.;BRUNET, E.;GARCIA, RUANO, J. L.;RODRIGUEZ, J. H.;SANCHEZ, F., J. CHEM. RES. MICROFICHE, 1982, N 10, 284-285
  作者：ALCUDIA, F.、BRUNET, E.、GARCIA, RUANO, J. L.、RODRIGUEZ, J. H.、SANCHEZ, F.

  DOI：——

  日期：——
• Alcudia Gonzalez, F.; Brunet Romero, E.; Garcia Ruano, J. L., Journal of Chemical Research, Miniprint, 1982, # 10, p. 2826 - 2850
  作者：Alcudia Gonzalez, F.、Brunet Romero, E.、Garcia Ruano, J. L.、Rodriguez Ramos, J. H.、Sanchez Alonso, F.

  DOI：——

  日期：——