2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-imidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-imidazo[1,2-a]pyridine
• 英文别名: 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)imidazo[1,2-a]pyridine
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: PJPWEMITJSQDRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ANTITUMOR DERIVATIVES FOR DIFFERENTIATION THERAPY
  申请人：THE CLEVELAND CLINIC FOUNDATION

  公开号：US20170253589A1

  公开（公告）日：2017-09-07

  Imidazopyridine derivatives according to formula I are described wherein X is selected from CH, N, S, and O, Y is selected from S, CO, and O, R 1 and optional R 2 are independently selected from H, OH, substituted or unsubstituted C 1 -C 6 alkyl, and substituted or unsubstituted C 4 -C 6 cycloalkyl or cycloheteroalkyl, R 3 is selected from H, OH, substituted or unsubstituted C 1 -C 6 alkyl, and optional Z is selected from OH, NH 2 , NH(CO)R 4 , NH(SO 2 )R 4 , guanidine, alkylguanidine, and fluoroguanidine, R 4 is polyethylene glycol or substituted or unsubstituted C 1 -C 6 alkyl, and pharmaceutically acceptable salt thereof. The imidazopyridine derivatives can be used for treatment of cancer in a subject.

  根据公式I描述的咪唑吡啶衍生物，其中X选自CH、N、S和O，Y选自S、CO和O，R1和可选的R2分别选自H、OH、取代或未取代的C1-C6烷基，以及取代或未取代的C4-C6环烷基或环杂烷基，R3选自H、OH、取代或未取代的C1-C6烷基，可选的Z选自OH、NH2、NH(CO)R4、NH(SO2)R4、胍、烷基胍和氟代胍，R4为聚乙二醇或取代或未取代的C1-C6烷基，及其药用盐。这些咪唑吡啶衍生物可用于治疗受试者的癌症。
• Substituted imidazo[1,2-A] pyridine derivatives
  申请人：——

  公开号：US20020188128A1

  公开（公告）日：2002-12-12

  The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1 wherein R 1 and R 2 are selected from hydrogen, (C 1-6 )-alkyl, halogen, hydroxy, (C 1-6 )-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.

  本发明涉及一系列新颖的化合物，化学式为I，并通过给予有效治疗剂量的化合物化学式1来治疗或预防mGluR5受体介导的疾病的方法，其中R1和R2从氢、(C1-6)-烷基、卤素、羟基、(C1-6)-烷氧基中选择，A在描述中有定义，或其药用盐。
• Substituted imidazo [1,2-a] pyridine derivatives
  申请人：——

  公开号：US20030212096A1

  公开（公告）日：2003-11-13

  The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1 wherein R 1 and R 2 are selected from hydrogen, (C 1-6 )-alkyl, halogen, hydroxy, (C 1-6 )-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.

  本发明涉及一系列新型化合物I的方法，以及通过给予化合物公式1的治疗有效量或预防mGluR5受体介导的疾病的方法，其中R1和R2选择自氢，(C1-6)-烷基，卤素，羟基，(C1-6)-烷氧基和A在说明中定义，或其药学上可接受的盐。
• Substituted imidazo[1,2-a]pyridine derivatives
  申请人：——

  公开号：US20040180921A1

  公开（公告）日：2004-09-16

  The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1 wherein R 1 and R 2 are selected from hydrogen, (C 1-6 )-alkyl, halogen, hydroxy, (C 1-6 )-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.

  本发明涉及一系列公式I的新化合物以及通过给予公式1中化合物的治疗有效量来治疗或预防mGluR5受体介导的疾病的方法，其中R1和R2选择自氢、(C1-6)烷基、卤素、羟基、(C1-6)烷氧基，A的定义如说明书所述，或其药学上可接受的盐。
• Antitumor derivatives for differentiation therapy
  申请人：THE CLEVELAND CLINIC FOUNDATION

  公开号：US10370373B2

  公开（公告）日：2019-08-06

  Imidazopyridine derivatives according to formula I are described wherein X is selected from CH, N, S, and O, Y is selected from S, CO, and O, R1 and optional R2 are independently selected from H, OH, substituted or unsubstituted C1-C6 alkyl, and substituted or unsubstituted C4-C6 cycloalkyl or cycloheteroalkyl, R3 is selected from H, OH, substituted or unsubstituted C1-C6 alkyl, and optional Z is selected from OH, NH2, NH(CO)R4, NH(SO2)R4, guanidine, alkylguanidine, and fluoroguanidine, R4 is polyethylene glycol or substituted or unsubstituted C1-C6 alkyl, and pharmaceutically acceptable salt thereof. The imidazopyridine derivatives can be used for treatment of cancer in a subject.

  根据式 I 描述了咪唑吡啶衍生物 其中 X 选自 CH、N、S 和 O，Y 选自 S、CO 和 O，R1 和任选的 R2 独立选自 H、OH、取代或未取代的 C1-C6 烷基和取代或未取代的 C4-C6 环烷基或环杂环烷基，R3 选自 H、OH、取代或未取代的 C1-C6 烷基，任选 Z 选自 OH、NH2、NH(CO)R4、NH(SO2)R4、胍、烷基胍和氟胍，R4 是聚乙二醇或取代或未取代的 C1-C6 烷基，以及它们的药学上可接受的盐。咪唑吡啶衍生物可用于治疗受试者的癌症。