[5-(Naphthalen-2-yloxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetic acid methyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [5-(Naphthalen-2-yloxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetic acid methyl ester
• 英文别名: methyl 2-[[5-(naphthalen-2-yloxymethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
• 化学式: C₁₆H₁₄N₂O₄S
• 分子量: 330.4
• InChiKey: BXEPRGARZQWUMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions
  申请人：BAR ILAN UNIVERSITY

  公开号：US11123339B2

  公开（公告）日：2021-09-21

  The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.

  本发明提供了调节威斯科特-阿尔德里奇综合征蛋白（WASp）降解和稳定性的特异性小分子化合物及其在先天性和获得性免疫相关疾病或病症中的方法和用途，特别是在原发性和继发性免疫缺陷中的方法和用途。
• WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS
  申请人：Bar-Ilan University

  公开号：EP3515435A1

  公开（公告）日：2019-07-31
• [EN] WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS<br/>[FR] PETITES MOLÉCULES DE PROTECTION DE WASP, COMPOSITIONS, PROCÉDÉS ET UTILISATIONS DE CELLES-CI DANS LE TRAITEMENT DE TROUBLES OU D'ÉTATS LIÉS À L'IMMUNITÉ INNÉE ET ACQUISE
  申请人：UNIV BAR ILAN

  公开号：WO2018055627A1

  公开（公告）日：2018-03-29

  The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.