5-十六酰氨基荧光黄 | 73024-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 5-十六酰氨基荧光黄
• 中文别名: 5-(N-十六烷酰)氨基荧光黄
• 英文名称: 5-Hexadecanoylaminofluorescein
• 英文别名: N-(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)hexadecanamide
• CAS: 73024-80-3
• 化学式: C₃₆H₄₃NO₆
• 分子量: 585.7
• InChiKey: QWSRVJGBAIRGMP-UHFFFAOYSA-N

物化性质

• 熔点：
  >142°C (dec.)
• 沸点：
  797.1±60.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  43
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Lipophilic dye-based FRET assays for clostridial toxin activity
  申请人：ALLERGAN, INC.

  公开号：EP2293064A1

  公开（公告）日：2011-03-09

  Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance energy transfer pair; and a Clostridial toxin recognition sequence including a cleavage site; and a membrane-associated second member of the FRET pair and methods useful for determining Clostridial toxin activity using such Clostridial toxin substrates.

  用于检测梭状芽孢杆菌毒素活性的组合物，该组合物包含一个细胞，该细胞包含与膜结合的梭状芽孢杆菌毒素底物，该底物包含荧光共振能量转移对的第一位成员；和包括裂解位点的梭状芽孢杆菌毒素识别序列；以及与膜结合的荧光共振能量转移对的第二位成员，以及使用这种梭状芽孢杆菌毒素底物确定梭状芽孢杆菌毒素活性的方法。
• Characterization of subvisible particles using a particle analyzer
  申请人：Baxalta Incorporated

  公开号：US10274500B2

  公开（公告）日：2019-04-30

  The present specification discloses methods of characterizing a population of particles using a particle analyzer. Particles may be characterized by size, absolute number, whether the particle is non-proteinaceous or proteinaceous, whether a proteinaceous particle has or lacks a certain physical property, or any combination thereof.

  本说明书公开了使用颗粒分析仪表征颗粒群的方法。颗粒可以通过大小、绝对数量、颗粒是非蛋白质还是蛋白质、蛋白质颗粒是否具有或缺乏某种物理特性或它们的任意组合来表征。
• Iterative optical based histology
  申请人：Kleinfeld David

  公开号：US20050035305A1

  公开（公告）日：2005-02-17

  Femtosecond laser pulses are used to iteratively cut and image fixed as well as exsanguinated fresh tissue. Such images help to automate three-dimensional histological analysis of biological tissue. Cuts are accomplished with approximately 0.3 to 100 microJoule pulses to ablate tissue with one-micrometer precision. Permeability, immunoreactivity, and optical clarity of the remaining tissue is retained after pulsed laser cutting. Samples from transgenic mice that express fluorescent proteins retained their fluorescence to within micrometers of the cut surface.

  飞秒激光脉冲用于迭代切割固定组织和新鲜组织并对其成像。这些图像有助于自动进行生物组织的三维组织学分析。切割用大约 0.3 到 100 微焦耳的脉冲完成，以一微米的精度消融组织。脉冲激光切割后，剩余组织的通透性、免疫活性和光学清晰度均得以保留。表达荧光蛋白的转基因小鼠样本的荧光保留在切割表面微米范围内。
• Emulsion particles for imaging and therapy and methods of use thereof
  申请人：Lanza M. Gregory

  公开号：US20050079131A1

  公开（公告）日：2005-04-14

  Emulsions preferably of nanoparticles formed from oil compounds coupled to a high Z number atom, said particles coated with a lipid/surfactant coating. The nanoparticles are made specific to targeted cells or tissues by coupling said nanoparticles to a ligand specific for the target cells or tissues. The nanoparticles may further include biologically active agents, radionuclides and/or other imaging agents.

  最好是由与高 Z 数原子偶联的油化合物形成的纳米颗粒的乳液，所述颗粒涂有脂质/表面活性剂涂层。通过将纳米颗粒与目标细胞或组织的特异性配体偶联，使纳米颗粒对目标细胞或组织具有特异性。纳米粒子可进一步包括生物活性剂、放射性核素和/或其他成像剂。
• Lipoparticles comprising proteins, methods of making, and using the same
  申请人：Doranz J. Benjamin

  公开号：US20050123563A1

  公开（公告）日：2005-06-09

  The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

  本发明涉及脂质颗粒。本发明还涉及脂质颗粒的生产。本发明还涉及包含病毒结构蛋白的脂质颗粒。本发明进一步涉及一种包含膜蛋白的脂质颗粒，该脂质颗粒可附着在传感器表面。本发明进一步涉及生产和使用脂质颗粒的方法，以评估蛋白质结合相互作用等。