1-[5-tert-Butyl-3-(2-dimethylamino-3,4-dioxo-cyclobut-1-enylamino)-2-methoxy-phenyl]-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-urea | 404009-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[5-tert-Butyl-3-(2-dimethylamino-3,4-dioxo-cyclobut-1-enylamino)-2-methoxy-phenyl]-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-urea
• 英文别名: [5-tert-Butyl-3-(2-dimethylamino-3,4-dioxo-cyclobut-1-enylamino)-2-methoxy-phenyl]-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-urea；1-[5-Tert-butyl-3-[[2-(dimethylamino)-3,4-dioxocyclobuten-1-yl]amino]-2-methoxyphenyl]-3-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]urea
• CAS: 404009-47-8
• 化学式: C₃₈H₄₂N₆O₅
• 分子量: 662.789
• InChiKey: HWVVYZHIKFFASK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  49
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Compounds useful as anti-inflammatory agents
  申请人：——

  公开号：US20020032195A1

  公开（公告）日：2002-03-14

  Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds. 1

  揭示了一种新颖的芳香化合物，其化学式为(I)，其中G、E、W、Ar、X、Y和Z。这些化合物可用于治疗涉及炎症的疾病或病理条件，如慢性炎症性疾病。还揭示了含有这些化合物的药物组合物以及制备这些化合物的方法。
• UREA COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1381594A1

  公开（公告）日：2004-01-21
• US6608052B2
  申请人：——

  公开号：US6608052B2

  公开（公告）日：2003-08-19
• [EN] COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS<br/>[FR] COMPOSES D'UREE UTILISES EN TANT QU'AGENTS ANTI-INFLAMMATOIRES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2002083642A1

  公开（公告）日：2002-10-24

  Disclosed are novel aromatic compounds of the formula (I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.