2-N,6-N-bis(2,3-dihydro-1,4-benzodioxin-6-yl)pyridine-2,6-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2-N,6-N-bis(2,3-dihydro-1,4-benzodioxin-6-yl)pyridine-2,6-dicarboxamide
• 化学式: C₂₃H₁₉N₃O₆
• 分子量: 433.42
• InChiKey: OYXWAOYMDAIYIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  吡啶-2,6-二甲酸 、 6-氨基-1,4-苯并二氧杂环 在 吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 2-N,6-N-bis(2,3-dihydro-1,4-benzodioxin-6-yl)pyridine-2,6-dicarboxamide
  参考文献：
  名称：

  Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells

  摘要：

  Small molecules based upon natural product dimers that exhibit cytotoxic activity were synthesized and evaluated for their anti-proliferative activity in human breast cancer cell lines. A central isophthalic core structure linking aromatic amines containing 3,5-disubstitutions produced the most active compounds. This series of compounds was found to be more active against the estrogen receptor positive cell line MCF-7 than the estrogen receptor negative cell line, SKBr3. (C)2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.014

文献信息

• ANTI MALARIAL COMPOUNDS
  申请人：INSTITUTO DE MEDICINA MOLECULAR

  公开号：US20220211698A1

  公开（公告）日：2022-07-07

  Disclosed herein are compositions and methods to prevent Plasmodium parasites from evading host cell autophagy responses, including by blocking binding of Plasmodium Upregulated in infective sporozoites 3 (UIS3) to host cell autophagy proteins, such as Microtubule-associated protein 1A/1B-light chain 3 (LC3).
• [EN] ANTI-MALARIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIPALUDIQUES
  申请人：[en]INSTITUTO DE MEDICINA MOLECULAR

  公开号：WO2022106892A1

  公开（公告）日：2022-05-27

  Disclosed herein are compositions and methods to preventPlasmodiumparasites from evading host cell autophagy responses, including by blocking binding ofPlasmodiumUpregulated in infective sporozoites 3 (UIS3) to host cell autophagy proteins, such as Microtubule-associated protein 1A/1 B-light chain 3 (LC3).