methyl N-[(5-nitrothiophen-2-yl)methylideneamino]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: methyl N-[(5-nitrothiophen-2-yl)methylideneamino]carbamate
• 化学式: C₇H₇N₃O₄S
• 分子量: 229.216
• InChiKey: WYBICGSVBZRQKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-硝基噻吩-2-甲醛 、 肼基甲酸甲酯 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以84%的产率得到methyl N-[(5-nitrothiophen-2-yl)methylideneamino]carbamate
  参考文献：
  名称：

  Small molecule “turn on” fluorescent probe for silver ion and application to bioimaging

  摘要：

  A simple thiophene based fluorescent probe 1 was prepared for the detection of Ag+ in aqueous solution. Probe 1 exhibits high selectivity and sensitivity toward Ag+ as fluorescence "off-on" behavior in HEPES buffered MeOH-H2O (1:1, (v/v) HEPES = 50 mM, pH = 7.4) solution. The detection limit was calculated to be 1.28 x 10 -7 M with an association constant of 1.58 x 10(6) M-1 by fluorescence titration experiments. The probe was also demonstrated to detect Ag+ in real samples and in living cells.

  DOI：

  10.1016/j.jphotochem.2018.04.027

文献信息

• Small molecule “turn on” fluorescent probe for silver ion and application to bioimaging
  作者：N. Bhuvanesh、S. Suresh、P. Ram Kumar、E.M. Mothi、K. Kannan、V. Rajesh Kannan、R. Nandhakumar

  DOI：10.1016/j.jphotochem.2018.04.027

  日期：2018.6

  A simple thiophene based fluorescent probe 1 was prepared for the detection of Ag+ in aqueous solution. Probe 1 exhibits high selectivity and sensitivity toward Ag+ as fluorescence "off-on" behavior in HEPES buffered MeOH-H2O (1:1, (v/v) HEPES = 50 mM, pH = 7.4) solution. The detection limit was calculated to be 1.28 x 10 -7 M with an association constant of 1.58 x 10(6) M-1 by fluorescence titration experiments. The probe was also demonstrated to detect Ag+ in real samples and in living cells.