N-(1-Methylpropyl)thioacetamid | 64528-54-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代酰胺
• 英文名称: N-(1-Methylpropyl)thioacetamid
• 英文别名: rac. N-sec.Butylthioacetamid；N-(2-Butyl)-thioacetamid；Auegrbjlpiybbq-uhfffaoysa-；N-butan-2-ylethanethioamide
• CAS: 64528-54-7；64528-64-9
• 化学式: C₆H₁₃NS
• mdl: MFCD19217543
• 分子量: 131.242
• InChiKey: AUEGRBJLPIYBBQ-UHFFFAOYSA-N

物化性质

• 沸点：
  120-121 °C(Press: 5 Torr)
• 密度：
  0.925±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  44.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-丁烷-2-基乙酰胺 在 tetraphosphorus decasulfide 、 potassium sulfide 作用下， 以 xylene 为溶剂， 生成 N-(1-Methylpropyl)thioacetamid
  参考文献：
  名称：

  Brunner,H.; Lukas,R., Chemische Berichte, 1979, vol. 112, # 7, p. 2528 - 2538

  摘要：

  DOI：

文献信息

• Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines
  申请人：Kshirsagar A. Tushar

  公开号：US20080015184A1

  公开（公告）日：2008-01-17

  Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having a urea substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本发明涉及在2-位具有脲基的咪唑吡啶，咪唑喹啉和咪唑萘啶化合物，含有这些化合物的药物组合物，中间体以及这些化合物的制备方法和使用方法，作为免疫调节剂，在动物中调节细胞因子生物合成，并用于治疗包括病毒和肿瘤疾病在内的疾病。
• Studies on organophosphorus compounds XXI. the dimer of p-methoxyphenylthionophosphine sulfide as thiation reagent. a new route to thiocarboxamides
  作者：S. Scheibye、B. S. Pedersen、S.-O. Lawesson

  DOI：10.1002/bscb.19780870311

  日期：——

  AbstractThe thiation properties of the dimer of p‐methoxyphenylthionophosphine sulfide, 1, has been investigated by performing reactions with a representative series of aliphatic and aromatic primary, secondary, and tertiary carboxamides in the temperature range 80‐100 °C using HMPA as solvent. This new method seems to be superior to all others as in most cases quantitative yields are found. Salicylanilide, when reacted with 1, in HMPA, yields salicylthioanilide and a new type of phosphorus heterocycle, 3, whose structure has been determined by NMR‐and X‐ray analyses. 13C NMR data are tabulated for a series of thioamide carbons.
• Dunina,V.V. et al., Journal of Organic Chemistry USSR (English Translation), 1977, vol. 13, p. 1493 - 1497
  作者：Dunina,V.V. et al.

  DOI：——

  日期：——
• DUNINA V. V.; PLUGINA R. I.; POTAPOV V. M.; RUXADZE E. G., ZH. ORGAN. XIMII, 1977, 13, HO 8, 1616-1620
  作者：DUNINA V. V.、 PLUGINA R. I.、 POTAPOV V. M.、 RUXADZE E. G.

  DOI：——

  日期：——
• ARYLOXY AND ARYLALKYLENEOXY SUBSTITUTED IMIDAZOQUINOLINES
  申请人：3M Innovative Properties Company

  公开号：EP1658076B1

  公开（公告）日：2013-03-06