Ro 60-0491 | 20949-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Ro 60-0491
• 英文别名: N-(3-Pyridyl)-N'-(β-naphthyl)harnstoff；1-naphthalen-2-yl-3-pyridin-3-yl-urea；N-(2-naphthyl)-N'-(3-pyridyl)-urea；1-naphthalen-2-yl-3-pyridin-3-ylurea
• CAS: 20949-53-5
• 化学式: C₁₆H₁₃N₃O
• 分子量: 263.299
• InChiKey: WSHWNJVHKYVMMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS
  申请人：Massachusetts Institute of Technology

  公开号：EP2387611A1

  公开（公告）日：2011-11-23
• US8940732B2
  申请人：——

  公开号：US8940732B2

  公开（公告）日：2015-01-27
• US9730945B2
  申请人：——

  公开号：US9730945B2

  公开（公告）日：2017-08-15
• [EN] DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS<br/>[FR] DIAGNOSTIC ET TRAITEMENT DE TROUBLES DU SPECTRE AUTISTIQUE
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2010083044A1

  公开（公告）日：2010-07-22

  The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and deficits in social behavior.
• [EN] METHODS, COMPOSITIONS, AND KITS FOR TREATING AND PREVENTING NEUROLOGICAL CONDITIONS<br/>[FR] PROCÉDÉS, COMPOSITIONS ET TROUSSES POUR TRAITER ET PRÉVENIR DES ÉTATS NEUROLOGIQUES
  申请人：IGNITE INST FOR INDIVIDUALIZED HEALTH

  公开号：WO2012149472A2

  公开（公告）日：2012-11-01

  Provided herein are methods, compositions, and kits for diagnosing, prognosing, treating, and/or preventing a neurological condition, e.g., autism spectrum disorder (ASD). Methods for treating and/or preventing ASD can comprise administering a transcriptional modulator, e.g., a histone deacetylase inhibitor, to a subject having or suspected of having a neurological condition, e.g., ASD. Methods of diagnosing and/or prognosing ASD can comprise determining the status of one or more biomarkers, e.g., genes, in a subject.