4-Chloro-2,3-diphenylfuro[2,3-b]pyridine | 937789-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 4-Chloro-2,3-diphenylfuro[2,3-b]pyridine
• CAS: 937789-88-3
• 化学式: C₁₉H₁₂ClNO
• 分子量: 305.763
• InChiKey: PPFGDXSUUZUBKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Chloro-2,3-diphenylfuro[2,3-b]pyridine 在 palladium diacetate potassium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 三氟乙酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 22.5h， 生成 2,3-diphenyl-N-(2-(1-piperazinyl)ethyl)furo[2,3-b]pyridin-4-amine
  参考文献：
  名称：

  Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties

  摘要：

  2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.048
• 作为产物：
  描述：

  7-Benzyl-2,3-diphenylfuro[2,3-b]pyridin-4-one 在 三氯氧磷 作用下， 反应 18.0h， 以57%的产率得到4-Chloro-2,3-diphenylfuro[2,3-b]pyridine
  参考文献：
  名称：

  Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties

  摘要：

  2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.048

文献信息

• US7674907B2
  申请人：——

  公开号：US7674907B2

  公开（公告）日：2010-03-09
• Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
  作者：Matthew W. Martin、John Newcomb、Joseph J. Nunes、Jean E. Bemis、David C. McGowan、Ryan D. White、John L. Buchanan、Erin F. DiMauro、Christina Boucher、Theodore Faust、Faye Hsieh、Xin Huang、Josie H. Lee、Stephen Schneider、Susan M. Turci、Xiaotian Zhu

  DOI：10.1016/j.bmcl.2007.01.048

  日期：2007.4

  2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties. (c) 2007 Elsevier Ltd. All rights reserved.