5-chloro-6-propoxy-[2]naphthoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-chloro-6-propoxy-[2]naphthoic acid
• 英文别名: 5-Chlor-6-propoxy-[2]naphthoesaeure；5-Chloro-6-propoxynaphthalene-2-carboxylic acid
• 化学式: C₁₄H₁₃ClO₃
• 分子量: 264.708
• InChiKey: AYEUKHPMWPZMSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Norvaline Derivative and Method for Preparation Thereof
  申请人：Harada Naoyuki

  公开号：US20080076769A1

  公开（公告）日：2008-03-27

  Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of said compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2). [wherein X is —CH 2 —, —O—, —S— or single bond; Ar is optionally substituted aryl or lower cycloalkyl; n is 0 to 2; R 1 and R 2 are (i) each is hydrogen or lower alkyl; (ii) R 1 and R 2 are combined to form lower alkylene; or (iii) R 1 is hydrogen or lower alkyl and R 2 is combined with R 4 or R 6 to form lower alkylene; R 3 and R 4 are (i) each is hydrogen or lower alkyl; (ii) R 3 and R 4 are combined to form lower alkylene; or (iii) R 3 is hydrogen or lower alkyl and R 4 is combined with R 2 or R 6 to form lower alkylene; R is or —OR 7 ; R 5 and R 6 are (i) each is optionally substituted lower alkyl, or hydrogen; (ii) R 5 and R 6 are combined to form aliphatic 5- to 6-membered heterocyclic group; or (iii) R 5 is optionally substituted lower alkyl or hydrogen and R 6 is combined with R 2 or R 4 to form lower alkylene; R 7 is lower alkyl.

  Norvaline衍生物的化学式[I]或其药学上可接受的盐，制备方法，含有该化合物的药物组合物，以及用于抑制甘氨酸转运体2型（GlyT2）的转运活性的用途。[其中X为-CH2-，-O-，-S-或单键；Ar为可选取代芳基或较低的环烷基；n为0至2；R1和R2为（i）氢或较低的烷基；（ii）R1和R2结合形成较低的烷基；或（iii）R1为氢或较低的烷基，R2与R4或R6结合形成较低的烷基；R3和R4为（i）氢或较低的烷基；（ii）R3和R4结合形成较低的烷基；或（iii）R3为氢或较低的烷基，R4与R2或R6结合形成较低的烷基；R为-OH或-OR7；R5和R6为（i）可选取代的较低烷基或氢；（ii）R5和R6结合形成脂肪族5-至6-成员杂环基；或（iii）R5为可选取代的较低烷基或氢，R6与R2或R4结合形成较低的烷基；R7为较低烷基。
• COMPOSITION AND METHOD FOR TEMPORARILY FIXING SOLID
  申请人：JSR Corporation

  公开号：EP1522567A1

  公开（公告）日：2005-04-13

  The present invention relates to a method of temporarily and firmly fixing two solids to each other and to a composition used in the method, which is a method of temporarily fixing, comprising temporarily fixing the two solids to each other with a liquid crystal compound or a composition comprising the liquid crystal compound. This method is used for a method of temporarily fixing a pad for chemical mechanical polishing, for example, to polish a wafer for a semiconductor device fixed on a surface of a base plate, when one solid is a pad for chemical mechanical polishing of a wafer for a semiconductor device and the other is a base plate to fix the pad.

  本发明涉及一种将两个固体暂时牢固地相互固定的方法以及用于该方法的组合物，该方法是一种暂时固定的方法，包括用液晶化合物或包含液晶化合物的组合物将两个固体暂时相互固定。该方法用于临时固定化学机械抛光垫的方法，例如，用于抛光固定在底板表面上的半导体器件晶片，其中一个固体是用于半导体器件晶片化学机械抛光的垫，另一个固体是用于固定垫的底板。
• Composition and method for temporarily fixing solid
  申请人：——

  公开号：US20040185187A1

  公开（公告）日：2004-09-23

  The present invention relates to a method of temporarily and firmly fixing two solids to each other and to a composition used in the method, which is a method of temporarily fixing, comprising temporarily fixing the two solids to each other with a liquid crystal compound or a composition comprising the liquid crystal compound. This method is used for a method of temporarily fixing a pad for chemical mechanical polishing, for example, to polish a wafer for a semiconductor device fixed on a surface of a base plate, when one solid is a pad for chemical mechanical polishing of a wafer for a semiconductor device and the other is a base plate to fix the pad.

  本发明涉及一种将两个固体暂时牢固地相互固定的方法以及用于该方法的组合物，该方法是一种暂时固定的方法，包括用液晶化合物或包含液晶化合物的组合物将两个固体暂时相互固定。该方法用于临时固定化学机械抛光垫的方法，例如，用于抛光固定在底板表面上的半导体器件晶片，其中一个固体是用于半导体器件晶片化学机械抛光的垫，另一个固体是用于固定垫的底板。
• NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1846366B1

  公开（公告）日：2011-08-03
• US7186448B2
  申请人：——

  公开号：US7186448B2

  公开（公告）日：2007-03-06