1,4-Bis-(5-formyl-2-thienyl)butane | 151534-70-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 1,4-Bis-(5-formyl-2-thienyl)butane
• 英文别名: 5,5'-(Butane-1,4-diyl)dithiophene-2-carbaldehyde；5-[4-(5-formylthiophen-2-yl)butyl]thiophene-2-carbaldehyde
• CAS: 151534-70-2
• 化学式: C₁₄H₁₄O₂S₂
• 分子量: 278.396
• InChiKey: DCBOSLCZMLUTSD-UHFFFAOYSA-N

物化性质

• 沸点：
  457.1±45.0 °C(predicted)
• 密度：
  1.275±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Fluorenylmethyltriphenylphosphonium bromide 、 1,4-Bis-(5-formyl-2-thienyl)butane 在 lithium methanolate 、 碘 作用下， 生成 E,E-1,4-Bis<5-(2-fluorenylvinyl)-2-thienyl>butane
  参考文献：
  名称：

  Kossmehl, Gerhard; Hoppe, Frank Dirk; Hirsch, Barbara, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1993, vol. 48, # 6, p. 826 - 843

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-噻吩-2-基丁基)噻吩 、 N,N-二甲基甲酰胺 在 正丁基锂 作用下， 生成 1,4-Bis-(5-formyl-2-thienyl)butane
  参考文献：
  名称：

  Kossmehl, Gerhard; Hoppe, Frank Dirk; Hirsch, Barbara, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1993, vol. 48, # 6, p. 826 - 843

  摘要：

  DOI：

文献信息

• Kossmehl, Gerhard; Hoppe, Frank Dirk, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1993, vol. 48, # 12, p. 1807 - 1820
  作者：Kossmehl, Gerhard、Hoppe, Frank Dirk

  DOI：——

  日期：——
• Kossmehl, G.; Hoppe, F. D., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 257, p. 169 - 180
  作者：Kossmehl, G.、Hoppe, F. D.

  DOI：——

  日期：——
• Insulin and IGF-1 receptor agonists and antagonists
  申请人：Pillutla Renuka

  公开号：US20070004634A1

  公开（公告）日：2007-01-04

  Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.
• INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS
  申请人：Pillutla Renuka

  公开号：US20070265189A1

  公开（公告）日：2007-11-15

  Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
• Insulin and IGF-1 Receptor Agonists and Antagonists
  申请人：Pillutla Renuka

  公开号：US20090053807A1

  公开（公告）日：2009-02-26

  Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.