1,4-Difluorocyclohexane | 116199-29-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1,4-Difluorocyclohexane
• CAS: 116199-29-2
• 化学式: C₆H₁₀F₂
• 分子量: 120.14
• InChiKey: XVITVIOGDRQODF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] HEXAHYDROPYRAZINOBENZ- OR -PYRIDO-OXAZEPINES CARRYING AN OXYGEN-CONTAINING SUBSTITUENT AND USE THEREOF IN THE TREATMENT OF 5-HT2C-DEPENDENT DISORDERS<br/>[FR] HEXAHYDROPYRAZINOBENZ- OU -PYRIDO-OXAZÉPINES TRANSPORTANT UN SUBSTITUANT CONTENANT DE L'OXYGÈNE ET SON UTILISATION POUR LE TRAITEMENT D'AFFECTIONS CONDITIONNÉES PAR 5-HT2C
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2017089458A1

  公开（公告）日：2017-06-01

  The present invention relates to compound of formula (I) (I) wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.

  本发明涉及通式(I)的化合物，其中变量如权利要求和说明书中所定义。本发明还涉及含有此类化合物的药物组合物，涉及它们作为调节剂，特别是5-HT2C受体的激动剂或部分激动剂的使用，涉及它们用于制备预防或治疗对5-HT2C受体调节有反应的病症和疾病的药物，以及涉及预防或治疗对5-HT2C受体调节有反应的病症和疾病的方法。
• QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
  申请人：Abbvie Deutschland GmbH & Co. KG

  公开号：US20170260158A1

  公开（公告）日：2017-09-14

  The present invention relates to quinoline compounds of formula I wherein the variables are defined as in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators of the 5-HT 6 receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of the 5-HT 6 receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of the 5-HT 6 receptor.

  本发明涉及公式I的喹啉化合物，其中变量的定义如索引和描述中所述。本发明还涉及含有这种化合物的药物组合物，以及它们作为5-HT6受体调节剂的用途，用于制备用于预防或治疗对5-HT6受体调节有反应的疾病和疾病的药物，以及用于预防或治疗对5-HT6受体调节有反应的疾病和疾病的方法。
• Substituted 1-(Azolin-2-yl)-Amino-1,2-Heterocyclyl-Ethane Compounds For Combating Pests
  申请人：Kordes Markus

  公开号：US20100041700A1

  公开（公告）日：2010-02-18

  The present invention relates to 1-(Azolin-2-yl)-amino-1,2-heterocyclyl-ethane compounds, which are useful for combating insects, arachnids and nematodes. The present invention also relates to methods for combating animal pests and to compositions for combating animal pests. It has been found that animal pests can be combated by 1-(Azolin-2-yl)-amino-1,2-heterocyclyl-ethane compounds of the general formula (I): wherein A is a radical of the formulae A 1 or A 2 : and wherein X is sulfur, oxygen or NR 7 , and Het A , Het B and R 1 to R 7 are defined as in the description.

  本发明涉及1-(Azolin-2-yl)-amino-1,2-杂环基-乙烷化合物，其可用于防治昆虫、蜘蛛和线虫。本发明还涉及用于防治动物害虫的方法和用于防治动物害虫的组合物。发现可以通过通式(I)的1-(Azolin-2-yl)-amino-1,2-杂环基-乙烷化合物来防治动物害虫，其中A是式A1或A2的基团：X是硫、氧或NR7，而HetA、HetB和R1到R7如描述中所定义。
• Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-HT6 receptor
  申请人：Abbvie Deutschland GmbH & Co. KG

  公开号：US10160744B2

  公开（公告）日：2018-12-25

  The present invention relates to quinoline compounds of formula I wherein the variables are defined as in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators of the 5-HT6 receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of the 5-HT6 receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of the 5-HT6 receptor.

  本发明涉及式 I 的喹啉化合物 其中变量的定义见权利要求和说明。本发明还涉及一种含有此类化合物的药物组合物、它们作为 5-HT6 受体调节剂的用途、它们用于制备预防或治疗对 5-HT6 受体调节有反应的病症和紊乱的药物的用途，以及预防或治疗对 5-HT6 受体调节有反应的病症和紊乱的方法。
• Polyarylether-based polymer with side chain in methoxypolyethylene glycols structure, solid polymer electrolyte and preparation methods therefor
  申请人：DALIAN UNIVERSITY OF TECHNOLOGY

  公开号：US11365286B2

  公开（公告）日：2022-06-21

  A polyarylether-based polymer with side chain in methoxypolyethylene glycols structure, a solid polymer electrolyte and preparation methods therefore are disclosed. The main chain of the polymer has a polymer structure containing a polyarylether group, the side chain has a methoxypolyethylene glycols structure, and the structural formula of the polyarylether-based polymer is as follows: and the preparation method for the polyarylether-based polymer with side chain in methoxypolyethylene glycols structure comprises: step (1): preparing a polymer containing a polyarylether group; and step (2): dissolving the polymer containing a polyarylether group and methoxypolyethylene glycols in a solvent, then adding a catalyst, dripping a co-catalyst after the catalyst is dissolved, and conducting reaction while stirring to obtain the polyarylether-based polymer with side chain in methoxypolyethylene glycols structure. The all-solid polymer electrolyte prepared by the present invention has favorable ionic conductivity and excellent heat resistance, high temperature resistance and mechanical strength.

  本发明公开了一种侧链为甲氧基聚乙二醇结构的聚芳醚基聚合物、一种固体聚合物电解质及其制备方法。该聚合物的主链具有含有聚芳醚基团的聚合物结构，侧链具有甲氧基聚乙二醇结构，聚芳醚基聚合物的结构式如下： 以及侧链为甲氧基聚乙二醇结构的聚芳醚基聚合物的制备方法，包括：步骤(1)：制备含有聚芳醚基团的聚合物；步骤(2)：将含有聚芳醚基团的聚合物和甲氧基聚乙二醇溶解在溶剂中，然后加入催化剂，待催化剂溶解后滴入助催化剂，边搅拌边进行反应，得到侧链为甲氧基聚乙二醇结构的聚芳醚基聚合物。本发明制备的全固态聚合物电解质具有良好的离子导电性和优异的耐热性、耐高温性和机械强度。