(6-chloro-2-phenyl-thiochromen-4-ylidene)-(3-morpholin-4-yl-propyl)-amine | 66799-68-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: (6-chloro-2-phenyl-thiochromen-4-ylidene)-(3-morpholin-4-yl-propyl)-amine
• CAS: 66799-68-6
• 化学式: C₂₂H₂₃ClN₂OS
• 分子量: 398.956
• InChiKey: DLNVDCKNNKFIPH-HIXSDJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.84
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  24.83
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 、 6-chloro-2-phenyl-thiochromene-4-thione 生成 (6-chloro-2-phenyl-thiochromen-4-ylidene)-(3-morpholin-4-yl-propyl)-amine
  参考文献：
  名称：

  A new class of antimalarial drugs: derivatives of benzothiopyrans

  摘要：

  A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160--360 mg/kg against Plasmodium berghei in mice. Afew observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.

  DOI：

  10.1021/jm00205a010

文献信息

• A new class of antimalarial drugs: derivatives of benzothiopyrans
  作者：Raj K. Razdan、Robert J. Bruni、Avinash C. Mehta、Klaus K. Weinhardt、Zinon B. Papanastassiou

  DOI：10.1021/jm00205a010

  日期：1978.7

  A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160--360 mg/kg against Plasmodium berghei in mice. Afew observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.