N-ethyl-N-((7-methoxydibenzo[b,d]furan-1-yl)methyl)ethanamine | 1421007-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-ethyl-N-((7-methoxydibenzo[b,d]furan-1-yl)methyl)ethanamine
• 英文别名: N-ethyl-N-[(7-methoxydibenzofuran-1-yl)methyl]ethanamine
• CAS: 1421007-17-1
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.37
• InChiKey: PKRJYQBHUXGYND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-溴-4-硝基苯甲醚 在 copper(I) oxide 、 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 硫酸 、 5%-palladium/activated carbon 、 氢气 、 potassium carbonate 、 potassium iodide 、 potassium hydroxide 、 sodium nitrite 作用下， 以 四氯化碳 、 乙醇 、 二氯甲烷 、 水 为溶剂， 170.0 ℃ 、3.0 MPa 条件下， 反应 14.0h， 生成 N-ethyl-N-((7-methoxydibenzo[b,d]furan-1-yl)methyl)ethanamine
  参考文献：
  名称：

  Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents

  摘要：

  Facing the multifactorial nature of Alzheimer's disease, twelve dibenzofuran/carbazole derivatives, which can be considered as the D-ring opened analogs of galantamine, have been designed and synthesized as multifunctional anti-Alzheimer agents. In vitro tests revealed that compounds 3 and 5, which bear a nitrate moiety in the molecule, showed a potent inhibition activity towards AChE and compound 3 showed a good A beta 42 aggregation inhibitory activity. Moreover, 3 and 5 could also release a relative low concentration of NO in vitro and they did not show toxicity to neuronal cells, while exerted a neuroprotective effect against the A beta-induced toxicity. More importantly, compound 3 showed a significant spatial memory improving effect in vivo, and a good safety in the ex vivo toxicity study. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.02.035