1,7,7-trimethyl-9-oxo-8H-furo[3,2-f]chromene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1,7,7-trimethyl-9-oxo-8H-furo[3,2-f]chromene-2-carboxamide
• 化学式: C₁₅H₁₅NO₄
• 分子量: 273.28
• InChiKey: QLXGFLIRQVNPAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  82.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP2892523A1

  公开（公告）日：2015-07-15
• EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3212773A1

  公开（公告）日：2017-09-06
• TREATMENT OF HEARING LOSS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3743057A1

  公开（公告）日：2020-12-02
• MASSIVELY PARALLEL DISCOVERY METHODS FOR OLIGONUCLEOTIDE THERAPEUTICS
  申请人：Roche Innovation Center Copenhagen A/S

  公开号：US20210071247A1

  公开（公告）日：2021-03-11

  The invention relates to the field of therapeutic oligonucleotide analytics and discovery, and provides methods for primer based parallel sequencing of modified oligonucleotides which provide sequence based quality information which may be used in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.
• QUALITY CONTROL OF LNA OLIGONUCLEOTIDE THERAPEUTICS USING MASSIVELY PARALLEL SEQUENCING
  申请人：ROCHE INNOVATION CENTER COPENHAGEN A/S

  公开号：US20220002796A1

  公开（公告）日：2022-01-06

  The invention relates to the field of therapeutic oligonucleotide analytics, and provides methods for primer based parallel sequencing of therapeutic oligonucleotides which provide sequence based quality information which may be used in conjunction with or in place of present chromatography or mass spectroscopic methods, and may be used, for example, in oligonucleotide therapeutic discovery, manufacture, quality assurance, therapeutic development, and patient monitoring.