(10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: (10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one
• 化学式: C₂₄H₃₆O₃
• 分子量: 372.5
• InChiKey: GECBBEABIDMGGL-MRTLOADZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NOVEL CANNABINERGIC COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS CANNABINERGIQUES ET LEURS UTILISATIONS
  申请人：UNIV NORTHEASTERN

  公开号：WO2014039042A1

  公开（公告）日：2014-03-13

  Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS.

  本发明涉及调节大麻素受体的化合物和组合物、调节大麻素受体的方法以及治疗与调节大麻素受体有关的各种疾病的方法。本公开涉及治疗大麻素依赖、神经病变、炎症、青光眼、神经退行性疾病、运动功能障碍、胃肠道疾病、低温、呕吐、食欲不振或艾滋病相关的厌食症的方法。
• SUPPOSITORIES COMPRISING CANNABINOIDS
  申请人：Axim Biotechnologies, Inc.

  公开号：EP3528784A1

  公开（公告）日：2019-08-28
• CANNABINOID AND SUGAR ALCOHOL COMPLEX, METHODS TO MAKE AND USE
  申请人：Axim Biotechnologies, Inc.

  公开号：US20200038421A1

  公开（公告）日：2020-02-06

  The present invention generally relates to a sugar alcohol and cannabinoid complex, and methods to prepare this complex from cannabinoid oil comprising at least one cannabinoid. The complex is in solid form and may be used in food, pharmaceutical, cosmetic formulations, and medical devices wherein solid forms of cannabinoid are desirable. This complex also enhances release of active cannabinoids in oral consumption. Methods to make this complex are also disclosed.
• [EN] SUPPOSITORIES COMPRISING CANNABINOIDS<br/>[FR] SUPPOSITOIRES COMPRENANT DES CANNABINOÏDES
  申请人：AXIM BIOTECHNOLOGIES INC

  公开号：WO2018075730A1

  公开（公告）日：2018-04-26

  This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucous membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Use of cannabinoids for the manufacture of suppositories to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention is also provided.