(3R)-3-methyl-2-prop-2-ynyl-3,4-dihydro-1H-isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (3R)-3-methyl-2-prop-2-ynyl-3,4-dihydro-1H-isoquinoline
• 化学式: C₁₃H₁₅N
• 分子量: 185.26
• InChiKey: JJHJQBCPOGEYKX-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] GAPDH CASCADE INHIBITOR COMPOUNDS AND METHODS OF USE AND TREATMENT OF STRESS INDUCED DISORDERS INCLUDING MENTAL ILLNESS<br/>[FR] COMPOSÉS INHIBITEURS DE CASCADE DE GAPDH, MÉTHODES D'UTILISATION ET TRAITEMENT DE TROUBLES INDUITS PAR LE STRESS, NOTAMMENT DE TROUBLES MENTAUX
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014035707A1

  公开（公告）日：2014-03-06

  The present invention provides compounds and composition comprising analogs of deprenyl and their use in the inhibition of nuclear GAPDH-Siahl binding and the activation of p300 and MEF2. Also provided herein are methods of prevention and treatment of stress induced disorders of the body, including, for example, major mental illness, such as schizophrenia, mood disorders, and addiction, as well as stress-associated diseases involving other organs, such as cardiac hypertrophy, in vivo, comprising administering to a mammal a therapeutically effective amount of analogs of deprenyl.