[9-[2-[4-[8-[4-[2-[2-[2-[[2-[4-(Diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamoyloxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]octanoyl]piperazine-1-carbonyl]phenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: [9-[2-[4-[8-[4-[2-[2-[2-[[2-[4-(Diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamoyloxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]octanoyl]piperazine-1-carbonyl]phenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;chloride
• 英文别名: [9-[2-[4-[8-[4-[2-[2-[2-[[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamoyloxy]ethoxy]ethoxy]ethoxymethyl]triazol-1-yl]octanoyl]piperazine-1-carbonyl]phenyl]-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;chloride
• 化学式: C71H89ClN11O11P
• 分子量: 1339.0
• InChiKey: OIJSVXMSDYLDEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.88
• 重原子数：
  95
• 可旋转键数：
  36
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  253
• 氢给体数：
  3
• 氢受体数：
  16

文献信息

• ACTIVITY-BASED PROBES FOR THE UROKINASE PLASMINOGEN ACTIVATOR
  申请人：Augustyns Koen

  公开号：US20140079632A1

  公开（公告）日：2014-03-20

  The present invention relates to selective trypsine-like serine protease activity-based probes, in particular urokinase plasminogen activator-activity based probes, the use thereof and methods for detecting selective urokinase activity by making use of said probes.

  本发明涉及选择性胰蛋白酶样丝氨酸蛋白酶活性探针，特别是以尿激酶纤溶酶原激活剂活性为基础的探针，其使用和利用该探针检测选择性尿激酶活性的方法。