N-(2-azidoethyl)-5-(methylaminomethyl)naphthalene-1-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-azidoethyl)-5-(methylaminomethyl)naphthalene-1-sulfonamide
• 化学式: C14H17N5O2S
• 分子量: 319.38
• InChiKey: MSIOWBMCCBDSDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  80.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• D-ALA-D-ALA-BASED DIPEPTIDES AS TOOLS FOR IMAGING PEPTIDOGLYCAN BIOSYNTHESIS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20160222430A1

  公开（公告）日：2016-08-04

  Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria using modified dipeptides containing a bioorthogonal tag and applying novel post-labeling methods to label the bioorthogonal tag. The resultant, labeled peptidoglycan structures are amenable for identifying bacteria by microscopic visualization.

  本文披露了一种用含有生物正交标记的修饰二肽评估细菌中肽聚糖生物合成的组合物，并应用新颖的后标记方法来标记生物正交标记。标记后的肽聚糖结构适合通过显微镜观察来识别细菌。
• Compositions for in situ labeling of bacterial cell walls with fluorophores and methods of use thereof
  申请人：Indiana University Research and Technology Corporation

  公开号：US10544444B2

  公开（公告）日：2020-01-28

  Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.

  本文公开了用于评估细菌肽聚糖生物合成、鉴定细菌和通过修饰的 D-氨基酸筛选细菌细胞壁作用剂和/或细胞壁破坏剂的组合物及其使用方法。还公开了具有一种或多种本文所述的改性 D-氨基酸的活细菌，这些改性 D-氨基酸被结合到细菌细胞壁的肽聚糖中。
• COMPOSITIONS FOR IN SITU LABELING OF BACTERIAL CELL WALLS WITH FLUOROPHORES AND METHODS OF USE THEREOF
  申请人：Indiana University and Technology Corporation

  公开号：US20150191763A1

  公开（公告）日：2015-07-09

  Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.
• [EN] COMPOSITIONS FOR IN SITU LABELING OF BACTERIAL CELL WALLS WITH FLUOROPHORES AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS POUR LE MARQUAGE IN SITU DE PAROIS CELLULAIRES BACTÉRIENNES PAR DES FLUOROPHORES, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2013159078A1

  公开（公告）日：2013-10-24

  Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacteria] cell wall-acting and/or wail- disrupting agents via modified D-amino acids and methods of use thereof Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.