2,3-Dihydroxypropyl 2,2,3-triphenylbutanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2,3-Dihydroxypropyl 2,2,3-triphenylbutanoate
• 英文别名: 2,3-dihydroxypropyl 2,2,3-triphenylbutanoate
• 化学式: C₂₅H₂₆O₄
• 分子量: 390.5
• InChiKey: HXNWETMYLMHHOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PROCEDURE FOR THE PREPARATION OF 4-PHENYL BUTYRATE AND USES THEREOF<br/>[FR] TECHNIQUE DE PRÉPARATION DE 4-PHÉNYLBUTYRATE ET SES UTILISATIONS
  申请人：HORIZON THERAPEUTICS LLC

  公开号：WO2017205515A1

  公开（公告）日：2017-11-30

  Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.

  提供了一种制备4-苯基-1-丁酸的过程，包括：在有机溶剂和磷酸盐缓冲液中使用氯酸钠、亚硝基自由基催化剂和次氯酸钠与4-苯基-1-丁醇反应；并使用亚硫酸钠淬灭反应以产生4-苯基-1-丁酸。同时提供了通过这种过程制备的4-苯基-1-丁酸。
• Procedure for the preparation of 4-phenyl butyrate and uses thereof
  申请人：Horizon Therapeutics, LLC

  公开号：US10329236B2

  公开（公告）日：2019-06-25

  Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.

  提供了一种制备 4-苯基-1-丁酸的工艺，包括：在有机溶剂和磷酸盐缓冲液中，使 4-苯基-1-丁醇与亚氯酸钠、硝基自由基催化剂和次氯酸钠反应；用亚硫酸钠淬灭反应，生成 4-苯基-1-丁酸。此外，还提供了通过这种工艺制备的 4-苯基-1-丁酸。
• TREATMENT OF MEDIUM-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：EP2838522A1

  公开（公告）日：2015-02-25
• Treatment of Medium-Chain Acyl-CoA Dehydrogenase Deficiency
  申请人：University of Pittsburgh - of the Commonwealth System of Higher Education

  公开号：US20150216824A1

  公开（公告）日：2015-08-06

  The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can serve as a substrate for medium chain acyl-CoA dehydrogenase. In non-limiting embodiments, phenylbutyrate and/or another source of phenylacetate is administered as a chaperone treatment to patients suffering from medium chain acyl-CoA dehydrogenase deficiency.
• TREATMENT OF MEDIUM-CHAIN ACYL-CoA DEHYDROGENASE DEFICIENCY
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20160166522A1

  公开（公告）日：2016-06-16

  The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can serve as a substrate for medium chain acyl-CoA dehydrogenase. In non-limiting embodiments, phenylbutyrate and/or another source of phenylacetate is administered as a chaperone treatment to patients suffering from medium chain acyl-CoA dehydrogenase deficiency.