N-(2-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-1-naphthamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-1-naphthamide
• 英文别名: N-[2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]naphthalene-1-carboxamide
• 化学式: C₂₅H₁₇F₃N₂O₂
• 分子量: 434.417
• InChiKey: FALIDTUFIYPOON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• MODULATORS OF THE RELAXIN RECEPTOR 1
  申请人：The United States of America, as Represented by the Secretary, Dept. of Health & Human Services

  公开号：US20150119426A1

  公开（公告）日：2015-04-30

  Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R 1 , and R 2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.

  本文揭示了人类松弛素受体1的调节剂，例如，公式（I）中的A、R1和R2如本文所定义，这些调节剂在治疗哺乳动物松弛素受体1介导的人类健康方面，例如心血管疾病中是有用的。还公开了一种包含药用适宜载体和本公开的至少一种化合物的组合物，以及一种用于治疗介导人类松弛素受体1的哺乳动物健康方面的干预方法。
• Modulators of the relaxin receptor 1
  申请人：The United States of America, as Represented by the Secretary, Department of Health and Human Service

  公开号：US10125112B2

  公开（公告）日：2018-11-13

  Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R1, and R2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.

  公开了人类松弛素受体1的调节剂，例如式（I），其中A、R1和R2如本文所定义，可用于治疗哺乳动物松弛素受体1介导的人类健康问题，例如心血管疾病。还公开了一种组合物，该组合物包含药学上合适的载体和至少一种本公开的化合物，以及一种治疗干预哺乳动物健康的方法，该哺乳动物的健康是由人类松弛素受体1介导的。
• US9452973B2
  申请人：——

  公开号：US9452973B2

  公开（公告）日：2016-09-27
• [EN] MODULATORS OF THE RELAXIN RECEPTOR 1<br/>[FR] MODULATEURS DU RÉCEPTEUR DE RELAXINE 1
  申请人：US HEALTH

  公开号：WO2013165606A1

  公开（公告）日：2013-11-07

  Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R1, and R2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.