4'-[2,3-bis[2,4,6-tri(propan-2-yl)phenyl]naphthalen-1-yl]-2-hydroxyspiro[1,3,2lambda5-dioxaphosphetane-4,3'-2H-naphthalene] 2-oxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4'-[2,3-bis[2,4,6-tri(propan-2-yl)phenyl]naphthalen-1-yl]-2-hydroxyspiro[1,3,2lambda5-dioxaphosphetane-4,3'-2H-naphthalene] 2-oxide
• 英文别名: 4'-[2,3-bis[2,4,6-tri(propan-2-yl)phenyl]naphthalen-1-yl]-2-hydroxyspiro[1,3,2λ5-dioxaphosphetane-4,3'-2H-naphthalene] 2-oxide
• 化学式: C₅₀H₅₉O₄P
• 分子量: 755.0
• InChiKey: HXXINNUVVQBBPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13
• 重原子数：
  55
• 可旋转键数：
  9
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] METHOD FOR SYNTHESIZING CYCLOALKANYL(B}INDOLES, CYCLOALKANYL(B) BENZOFURANS, CYCLOALKANYL(B)BENZOTHIOPHENES, COMPOUNDS AND METHODS OF USE<br/>[FR] PROCÉDÉ PERMETTANT DE SYNTHÉTISER DES CYCLOALCANYL[B]INDOLES, DES CYCLOALCANYL[B]BENZOFURANES, DES CYCLOALCANYL[B]BENZOTHIOPHÈNES, COMPOSÉS ET PROCÉDÉS D'UTILISATION
  申请人：DARTMOUTH COLLEGE

  公开号：WO2013177241A1

  公开（公告）日：2013-11-28

  A method of synthesizing cycloalkanyl [b] indoles, as well as related cycloalkanyl [b] benzofurans and cycloalkanyl [b] benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In (III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-l or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided.

  提供了一种合成环戊基[b]吲哚的方法，以及相关的环戊基[b]苯并呋喃和环戊基[b]苯并噻吩。该方法是一种单一的多组分反应，结合了（1）吲哚、苯并呋喃或苯并噻吩，（2）醛、酮或缩醛，以及（3）二烯，存在酸的情况下进行，特别是Ga(III)或In(III)盐。还提供了使用这些化合物刺激分泌和/或产生胰高血糖素样肽-1或抑制降钙素基因相关肽受体活性的组合物和方法。
• METHOD FOR SYNTHESIZING CYCLOALKANYL(B}INDOLES, CYCLOALKANYL(B) BENZOFURANS, CYCLOALKANYL(B)BENZOTHIOPHENES, COMPOUNDS AND METHODS OF USE
  申请人：Trustees of Dartmouth College

  公开号：EP2887804A1

  公开（公告）日：2015-07-01