3,4-dihydroxy-9-(2-hydroxyacetyl)-2-methoxy-9-methyl-8,10-dihydro-7H-tetracene-5,12-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 3,4-dihydroxy-9-(2-hydroxyacetyl)-2-methoxy-9-methyl-8,10-dihydro-7H-tetracene-5,12-dione
• 化学式: C₂₂H₂₀O₇
• 分子量: 396.4
• InChiKey: SKQGJOJWTSVNCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• DIAGNOSIS AND THERAPY OF CANCER INVOLVING CANCER STEM CELLS
  申请人：Biontech AG

  公开号：EP3027208A1

  公开（公告）日：2016-06-08
• [EN] COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER<br/>[FR] POLYTHÉRAPIE IMPLIQUANT DES ANTICORPS DIRIGÉS CONTRE LA CLAUDINE 18,2 POUR LE TRAITEMENT DU CANCER
  申请人：GANYMED PHARMACEUTICALS AG

  公开号：WO2013174403A1

  公开（公告）日：2013-11-28

  The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head -neck cancer, and cancer of the gallbladder and metastases thereof.
• [EN] DIAGNOSIS AND THERAPY OF CANCER INVOLVING CANCER STEM CELLS<br/>[FR] DIAGNOSTIC ET THÉRAPIE DE CANCER IMPLIQUANT DES CELLULES SOUCHES CANCÉREUSES
  申请人：BIONTECH AG

  公开号：WO2015014870A1

  公开（公告）日：2015-02-05

  The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.