N-propylnaphthalene-1-carboxamide | 78151-22-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-propylnaphthalene-1-carboxamide
• CAS: 78151-22-1
• 化学式: C₁₄H₁₅NO
• mdl: MFCD01342085
• 分子量: 213.279
• InChiKey: CRXGWGIJJCBJLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正丙胺 、 1-萘甲醛 在 碘苯二乙酸 、 水 作用下， 以 氯仿 为溶剂， 反应 20.0h， 以53%的产率得到N-propylnaphthalene-1-carboxamide
  参考文献：
  名称：

  从醛和胺中氧化形成酰胺的温和清洁方法

  摘要：

  报道了使用高价碘 (III) 试剂或离子支持的高价碘 (III) 试剂作为可回收氧化剂在温和条件下从醛和胺中无金属直接氧化形成酰胺。

  DOI：

  10.1055/s-2008-1078218

文献信息

• Amine derivatives, processes for preparing the same and fungicides containing the same
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP0164697A2

  公开（公告）日：1985-12-18

  Amine derivatives having the general formula (I): wherein X is selected from the group consisting of wherein Q is oxygen, sulfur or nitrogen atom, and wherein Q is as above; Y is selected from the group consisting of R' is hydrogen atom or an alkyl group; R2 is hydrogen atom or an alkyl group; R3 is hydrogen atom, a halogen atom or an alkyl group; R4 is hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R5 is attached to an arbitrary position of X, and R3 or R4 is attached to an arbitrary position of Y. The amine derivatives (II are useful as fungicides.

  具有通式(I)的胺衍生物：其中X选自由Q为氧、硫或氮原子组成的组，Q如上；Y选自由R'为氢原子或烷基；R2为氢原子或烷基；R3为氢原子、卤素原子或烷基；R4为氢原子、烷基、环烷基、卤代烷基或卤素原子；R5为氢原子、烷基、烷氧基、卤素原子、硝基或羟基；R5连接到X的任意位置，R3或R4连接到Y的任意位置。
• α- and γ-truxillic acid derivatives and pharmaceutical compositions thereof
  申请人：The Research Foundation for The State University of New York

  公开号：US11026910B2

  公开（公告）日：2021-06-08

  The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

  本发明提供了一种化合物和抑制脂肪酸结合蛋白（FABP）活性的方法，该方法包括使脂肪酸结合蛋白与具有以下结构的化合物接触：
• α-Substitution Effects on the Ease of<i>S</i>→<i>N</i>-Acyl Transfer in Aminothioesters
  作者：Bahaa El-Dien M. El-Gendy、Ebrahim H. Ghazvini Zadeh、Ania C. Sotuyo、Girinath G. Pillai、Alan R. Katritzky

  DOI：10.1111/cbdd.12092

  日期：2013.5

  In S‐acylcysteines and homocysteines, the efficacy and rate of S→N‐acyl transfer (5 and 6 cyclic TSs) vary with the size of S‐acyl group. Conformational and quantum chemical calculations indicate that the spatial distance, b(N‐C), between the terminal amine and the thioester carbon is shortened by α‐C(O)X (X = OH, OMe, NH2) substituents.
• Process for the preparation of (2S)-tetrahydro-2alpha-methyl-6-oxo-4beta-amino-2H-pyran-3alpha-carboxylic acid esters
  申请人：Merck & Co., Inc.

  公开号：EP0062840B1

  公开（公告）日：1987-12-16
• ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Ojima Iwao

  公开号：US20190201365A1

  公开（公告）日：2019-07-04

  The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure: