3-[6-(Cyanomethyl)naphthalen-2-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-[6-(Cyanomethyl)naphthalen-2-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• 英文别名: 3-[6-(cyanomethyl)naphthalen-2-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• 化学式: C₂₀H₂₂N₂O₄
• 分子量: 354.4
• InChiKey: PTYIBLDZTHELNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  99.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ONE STEP N-TERMINAL TAGGING OF PROTEINS<br/>[FR] MARQUAGE N-TERMINAL EN UNE SEULE ÉTAPE DES PROTÉINES
  申请人：UNIV PENNSYLVANIA

  公开号：WO2013188607A1

  公开（公告）日：2013-12-19

  A selective method of modifying the N-terminus a protein using an aminoacyl tRNA transferase is provided. The method comprises reacting the protein with the aminoacyl adenosyl derivative, recognizable by AaT t-RNA transferase derived from E.Coli and similar bacterial systems. The method further includes production of protein fusion constructs by incorporation of an additional cysteine in the N -terminus and reacting this cysteine with a thioether placed on the C-terminus of a reaction partner protein, producing a fused construct. Selenocysteine can be included in the fused construct and further reduced producing alanine residue in the desired positions. An essential feature of the method is that the aminoacyl adenosine derivatives are pre-made and do not require a synthetase enzyme, allowing a great diversity of the N-terminus modifiers to be pre-made synthetically. The method is implemented as a kit.
• [EN] NOVEL METHODS OF IDENTIFYING PROTEINS VIA N-TERMINAL TAGGING AND SELECTIVE PULL-DOWN<br/>[FR] NOUVEAUX PROCÉDÉS D'IDENTIFICATION DE PROTÉINES PAR ÉTIQUETAGE N-TERMINAL ET EXTRACTION SÉLECTIVE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2013188635A2

  公开（公告）日：2013-12-19

  The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase.