3-[3-(1-Adamantylamino)-2-hydroxypropoxy]naphthalene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-[3-(1-Adamantylamino)-2-hydroxypropoxy]naphthalene-2-carboxylic acid
• 英文别名: 3-[3-(1-adamantylamino)-2-hydroxypropoxy]naphthalene-2-carboxylic acid
• 化学式: C₂₄H₂₉NO₄
• 分子量: 395.5
• InChiKey: RJSICDVLJDIPGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• AMIDOPHENOXYPROPANOLAMINES
  申请人：MEDIZINISCHE UNIVERSITÄT WIEN

  公开号：US20150141437A1

  公开（公告）日：2015-05-21

  The use of compounds of formula wherein R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have several meanings, for the treatment of disorders mediated by protozoan organisms, novel compounds of the above formula and intermediates for the preparation of such compounds, pharmaceutical compositions comprising such novel compounds, a method of treating disorders mediated by protozoan organisms comprising administering such compounds, optionally together with a second drug substance, to a subject in need thereof and the use of such compounds, whenever comprising a photoaffinity label, for the identification of the molecular target(s) of arylamino alcohol antimalarials.

  使用公式化合物，其中R2，R3，R4，R5，R6和R7具有多种含义，用于治疗由原虫引起的疾病，上述公式的新化合物和制备这种化合物的中间体，包括这种新化合物的药物组合物，治疗由原虫引起的疾病的方法，包括向需要该化合物的受试者施用该化合物，可选择地与第二种药物物质一起使用，以及使用这种化合物，无论是否包含光致亲和标记，来鉴定芳基氨基醇抗疟药的分子靶点。
• [EN] AMIDOPHENOXYPROPANOLAMINES<br/>[FR] AMIDOPHÉNOXYPROPANOLAMINES
  申请人：UNIV WIEN MED

  公开号：WO2013186153A2

  公开（公告）日：2013-12-19

  The use of compounds of formula wherein R2, R3, R4, R5, R6 and R7 have several meanings, for the treatment of disorders mediated by protozoan organisms, novel compounds of the above formula and intermediates for the preparation of such compounds, pharmaceutical compositions comprising such novel compounds, a method of treating disorders mediated by protozoan organisms comprising administering such compounds, optionally together with a second drug substance, to a subject in need thereof and the use of such compounds, whenever comprising a photoaffinity label, for the identification of the molecular target(s) of arylamino alcohol antimalarials.