1-[3-[7-(4-Ethylcyclohexyl)oxy-8-(trifluoromethyl)naphthalen-2-yl]propyl]piperidine-4-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[3-[7-(4-Ethylcyclohexyl)oxy-8-(trifluoromethyl)naphthalen-2-yl]propyl]piperidine-4-carboxylic acid
• 英文别名: 1-[3-[7-(4-ethylcyclohexyl)oxy-8-(trifluoromethyl)naphthalen-2-yl]propyl]piperidine-4-carboxylic acid
• 化学式: C₂₈H₃₆F₃NO₃
• 分子量: 491.6
• InChiKey: KVIVFAHYNYAYDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ATX MODULATING AGENTS
  申请人：Biogen Idec MA Inc.

  公开号：EP2877166A1

  公开（公告）日：2015-06-03
• [EN] ATX MODULATING AGENTS<br/>[FR] AGENTS DE MODULATION D'ATX
  申请人：BIOGEN IDEC INC

  公开号：WO2014018881A1

  公开（公告）日：2014-01-30

  Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.