5-[2-(4-Aminobutanoyloxy)ethylcarbamothioylamino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[2-(4-Aminobutanoyloxy)ethylcarbamothioylamino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
• 英文别名: 5-[2-(4-aminobutanoyloxy)ethylcarbamothioylamino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
• 化学式: C₂₇H₂₅N₃O₇S
• 分子量: 535.6
• InChiKey: ODNUUCKCLYZJLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  192
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Compositions and methods of using the compositions for plaque softening
  申请人：ALUMEND, LLC

  公开号：US10131635B2

  公开（公告）日：2018-11-20

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本文公开了一种用于血管的组合物中的化合物，其中的化合物可软化和/或破坏钙化斑块的结晶基质。还公开了包括应用所公开组合物的治疗方法。还公开了斑块软化化合物。
• COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING
  申请人：Alumend, LLC

  公开号：EP2970227A1

  公开（公告）日：2016-01-20
• [EN] COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING<br/>[FR] COMPOSITIONS ET MÉTHODES D'UTILISATION DES COMPOSITIONS POUR RAMOLLIR DES PLAQUES CALCIFIÉES
  申请人：ALUMEND LLC

  公开号：WO2014022807A2

  公开（公告）日：2014-02-06

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.
• [EN] COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'UTILISATION DES COMPOSITIONS POUR ASSOUPLISSEMENT DE PLAQUE
  申请人：ALUMEND LLC

  公开号：WO2014149198A1

  公开（公告）日：2014-09-25

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.