5-(4-Aminobutylamino)-2-(naphthalen-2-ylamino)-1,3-thiazole-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(4-Aminobutylamino)-2-(naphthalen-2-ylamino)-1,3-thiazole-4-carboxamide
• 英文别名: 5-(4-aminobutylamino)-2-(naphthalen-2-ylamino)-1,3-thiazole-4-carboxamide
• 化学式: C₁₈H₂₁N₅OS
• 分子量: 355.5
• InChiKey: HWZUSAOGEVCXIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• NOVEL BICYCLIC THIAZOLE COMPOUNDS
  申请人：Carna Biosciences, Inc.

  公开号：EP2855470A1

  公开（公告）日：2015-04-08
• [EN] NOVEL BICYCLIC THIAZOLE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS THIAZOLES BICYCLIQUES
  申请人：CARNA BIOSCIENCES INC

  公开号：WO2013176293A1

  公开（公告）日：2013-11-28

  The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.