3,3-Dimethyl-6-phenyl-1-(2-phenylethyl)piperazin-2-one | 1172602-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3,3-Dimethyl-6-phenyl-1-(2-phenylethyl)piperazin-2-one
• 英文别名: 3,3-dimethyl-6-phenyl-1-(2-phenylethyl)piperazin-2-one
• CAS: 1172602-42-4
• 化学式: C₂₀H₂₄N₂O
• 分子量: 308.423
• InChiKey: GRAZALGSZPLAGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Methyl 2-(2-oxo-2-phenylethyl)aminoisobutyrate 、 2-苯乙胺 在 sodium cyanoborohydride 、 丙酮 作用下， 以 甲醇 为溶剂， 以65%的产率得到3,3-Dimethyl-6-phenyl-1-(2-phenylethyl)piperazin-2-one
  参考文献：
  名称：

  Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones

  摘要：

  The convenient preparation of novel 6-phenylpiperazin-2-ones from simple starting materials via a practical two-step procedure is presented. This methodology involves an initial alkylation of 2-bromoacetophenone with an amino ester followed by a one-pot reductive amination and cyclization step to furnish the desired substituted piperazinones. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.036

文献信息

• Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones
  作者：Steven N. Gallicchio、Ian M. Bell

  DOI：10.1016/j.tetlet.2009.04.036

  日期：2009.7

  The convenient preparation of novel 6-phenylpiperazin-2-ones from simple starting materials via a practical two-step procedure is presented. This methodology involves an initial alkylation of 2-bromoacetophenone with an amino ester followed by a one-pot reductive amination and cyclization step to furnish the desired substituted piperazinones. (C) 2009 Elsevier Ltd. All rights reserved.