1-[4-[1-(Diethylamino)ethoxy]phenyl]-1,2-diphenylethanol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[4-[1-(Diethylamino)ethoxy]phenyl]-1,2-diphenylethanol
• 英文别名: 1-[4-[1-(diethylamino)ethoxy]phenyl]-1,2-diphenylethanol
• 化学式: C₂₆H₃₁NO₂
• 分子量: 389.5
• InChiKey: XLGDGGJKSCNHSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TRANS-CLOMIPHENE FORMULATIONS AND USES THEREOF
  申请人：Repros Therapeutics Inc.

  公开号：EP2887922A1

  公开（公告）日：2015-07-01
• [EN] TRANS-CLOMIPHENE FORMULATIONS AND USES THEREOF<br/>[FR] FORMULATIONS TRANS-CLOMIPHÈNES ET LEURS UTILISATIONS
  申请人：REPROS THERAPEUTICS INC

  公开号：WO2014031177A1

  公开（公告）日：2014-02-27

  The present invention provides iraws-clomiphene and pharmaceutically acceptable salts and solvates thereof, characterized in that trans -clomiphene is in particulate form having a specific size range. The invention is also directed to pharmaceutical compositions comprising or formulated using trans -clomiphene or pharmaceutically acceptable satls and solvates having a specified size range and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.