(2R)-2-[(4-aminophenyl)methyl]-2-methoxy-3-oxobutanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (2R)-2-[(4-aminophenyl)methyl]-2-methoxy-3-oxobutanoic acid
• 化学式: C₁₂H₁₅NO₄
• 分子量: 237.25
• InChiKey: IHTABYJTVMTSMK-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] METHODS OF INHIBITING HAIR GROWTH<br/>[FR] PROCÉDÉS D'INHIBITION DE LA CROISSANCE PILEUSE
  申请人：NOGRA PHARMA LTD

  公开号：WO2014041141A1

  公开（公告）日：2014-03-20

  Provided herein are methods for reducing mammalian hair growth using the disclosed compounds. Also provided herein are methods of inhibiting hair growth after hair removal of an area of mammalian skin of a mammal using the disclosed compounds.

  本文提供了使用披露的化合物减少哺乳动物毛发生长的方法。本文还提供了使用披露的化合物抑制哺乳动物皮肤区域脱毛后毛发生长的方法。
• METHODS OF INHIBITING HAIR GROWTH
  申请人：Nogra Pharma Limited

  公开号：EP2897603A1

  公开（公告）日：2015-07-29
• [EN] COMPOSITIONS FOR RECTAL ADMINISTRATION IN THE TREATMENT OF ULCERATIVE COLITIS AND METHODS OF USING SAME<br/>[FR] COMPOSITIONS POUR UNE ADMINISTRATION PAR VOIE RECTALE DANS LE TRAITEMENT DE LA COLITE ULCÉREUSE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：NOGRA PHARMA LTD

  公开号：WO2017046343A1

  公开（公告）日：2017-03-23

  Disclosed herein are compositions comprising 3-(4-aminophenyl)-2-methoxypropionic acid or pharmaceutically acceptable salts or stereoisomers thereof useful for treating ulcerative colitis and other inflammatory bowel disorders and suitable for rectal administration. Also disclosed are containers useful for housing and administering such compositions. Also disclosed are kits comprising compositions of the invention as well as, in some embodiments, containers for housing and administering such compositions. Also disclosed are methods of treating inflammatory bowel disease in a patient in need by administering compositions of the invention rectally.