N-[[(4S,9E)-9-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4,6,7,8-tetrahydro-3H-pyrido[2,1-c][1,2,4]oxadiazin-4-yl]methyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[[(4S,9E)-9-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4,6,7,8-tetrahydro-3H-pyrido[2,1-c][1,2,4]oxadiazin-4-yl]methyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
• 化学式: C₃₁H₃₅N₅O₃
• 分子量: 525.6
• InChiKey: DYWJSKNRVOLVME-QKUAQCGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  81
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• GAMMA SECRETASE MODULATORS
  申请人：Zhu Zhaoning

  公开号：US20110294756A1

  公开（公告）日：2011-12-01

  In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
• US8673900B2
  申请人：——

  公开号：US8673900B2

  公开（公告）日：2014-03-18