3'-ethyl-6'-(4-ethylcyclohexen-1-yl)-2',2'-dimethyl-3'-propylspiro[5H-1,3-oxazole-4,4'-chromene]-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3'-ethyl-6'-(4-ethylcyclohexen-1-yl)-2',2'-dimethyl-3'-propylspiro[5H-1,3-oxazole-4,4'-chromene]-2-amine
• 化学式: C₂₆H₃₈N₂O₂
• 分子量: 410.6
• InChiKey: RBSVXTKQTLNAIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] CHROMANE COMPOUNDS<br/>[FR] COMPOSÉS DE CHROMANE
  申请人：ASTELLAS PHARMA INC

  公开号：WO2013181202A2

  公开（公告）日：2013-12-05

  The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β -amyloid precursor protein, and/or β -amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.